Role of central epinephrine in regulation of anterior pituitary hormone secretion
dc.contributor.author | Terry, L. Cass | en_US |
dc.contributor.author | Crowley, W. R. | en_US |
dc.contributor.author | Lynch, C. | en_US |
dc.contributor.author | Longserre, C. | en_US |
dc.contributor.author | Johnson, M. D. | en_US |
dc.date.accessioned | 2006-04-07T17:52:36Z | |
dc.date.available | 2006-04-07T17:52:36Z | |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | Terry, L. Cass, Crowley, W. R., Lynch, C., Longserre, C., Johnson, M. D. (1982)."Role of central epinephrine in regulation of anterior pituitary hormone secretion." Peptides 3(3): 311-318. <http://hdl.handle.net/2027.42/23999> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47T8VTG-6X/2/d8ccfb7040558e95bb868457d7b4fd4a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23999 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6750566&dopt=citation | en_US |
dc.description.abstract | Hypothalamic regulation of anterior pituitary hormones is thought to be mediated by the release of stimulatory and/or inhibitory peptides that are, in turn, regulated by catecholaminergic neurons. The recent development of selective epinephrine (EPI) synthesis inhibitors has made it possible to disrupt central EPI neurotransmission without affecting norepinephrine or dopamine. These compounds were used in the present investigation to assess the involvement of brain EPI systems in regulation of GH, LH, and prolactin (PRL) in male and ovariectomized female rats. Inhibition of central EPI synthesis (1) inhibited episodic and morphine-, but not clonidine-induced GH release, and (2) blocked the LH surge induced by estrogen and progesterone, but did not affect episodic LH release in hormonally untreated rats. Inhibition of peripheral (adrenal) EPI synthesis had no effect on these hormones. Results of these studies suggest an excitatory role for EPI in regulation of GH and LH secretion, mediated by stimulation of GH-releasing hormone and LHRH, respectively. EPI does not appear to have a major function in regulation of PRL secretion. | en_US |
dc.format.extent | 807388 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Role of central epinephrine in regulation of anterior pituitary hormone secretion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA: Department of Pharmacology, University of Tennessee Center for Health Sciences, Memphis, TN 38163, USA: VA Medical Center, University of Michigan, Ann Arbor, MI 48105, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA: Department of Pharmacology, University of Tennessee Center for Health Sciences, Memphis, TN 38163, USA: VA Medical Center, University of Michigan, Ann Arbor, MI 48105, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA: Department of Pharmacology, University of Tennessee Center for Health Sciences, Memphis, TN 38163, USA: VA Medical Center, University of Michigan, Ann Arbor, MI 48105, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA: Department of Pharmacology, University of Tennessee Center for Health Sciences, Memphis, TN 38163, USA: VA Medical Center, University of Michigan, Ann Arbor, MI 48105, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA: Department of Pharmacology, University of Tennessee Center for Health Sciences, Memphis, TN 38163, USA: VA Medical Center, University of Michigan, Ann Arbor, MI 48105, USA | en_US |
dc.identifier.pmid | 6750566 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23999/1/0000248.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(82)90092-4 | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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