Effect of Ca2+ on thermotropic properties of saturated phosphatidylcholine liposomes
dc.contributor.author | Ganesan, Madurai G. | en_US |
dc.contributor.author | Schwinke, David L. | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.date.accessioned | 2006-04-07T17:52:54Z | |
dc.date.available | 2006-04-07T17:52:54Z | |
dc.date.issued | 1982-04-07 | en_US |
dc.identifier.citation | Ganesan, Madurai G., Schwinke, David L., Weiner, Norman (1982/04/07)."Effect of Ca2+ on thermotropic properties of saturated phosphatidylcholine liposomes." Biochimica et Biophysica Acta (BBA) - Biomembranes 686(2): 245-248. <http://hdl.handle.net/2027.42/24008> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1T-47STWCV-2P/2/52eee655abad352ab25123b50774e193 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24008 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6896286&dopt=citation | en_US |
dc.description.abstract | The effect of various concentrations of calcium ion (Ca2+) on dipalmitoylphosphatidylcholine (DPPC), distearoylphosphatidylcholine (DSPC) and mixed DPPC/DSPC (1:1) liposomes was studied by differential scanning calorimetry. Ca2+ concentrations of 10 mM and above split the main transition peak of DPPC into two distinguishable components, and, at 30 mM and above, also resulted in the disappearance of a pre-transition peak. The effect of Ca2+ on DSPC liposomes was even more dramatic in that it induced a more definitive split in the main transition peak and caused the loss of the pretransition peak at only 10 mM concentration. The thermograms of the DPPC/DSPC mixed liposomes were unaltered in the presence of Ca2+, even at a concentration of 50 mM. Whether or not Ca2+ is able to alter thermograms of phosphatidylcholine liposomes appears to be dependent on the degree of molecular order of the bilayer prior to interaction with Ca2+. | en_US |
dc.format.extent | 259725 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of Ca2+ on thermotropic properties of saturated phosphatidylcholine liposomes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6896286 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24008/1/0000257.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2736(82)90119-5 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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