Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action
dc.contributor.author | Werz, Mary Ann | en_US |
dc.contributor.author | MacDonald, Robert L. | en_US |
dc.date.accessioned | 2006-04-07T17:53:39Z | |
dc.date.available | 2006-04-07T17:53:39Z | |
dc.date.issued | 1982-03-18 | en_US |
dc.identifier.citation | Werz, Mary Ann, MacDonald, Robert L. (1982/03/18)."Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action." Brain Research 236(1): 107-119. <http://hdl.handle.net/2027.42/24031> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4836007-1DJ/2/c40285947fab3bf58ab4db494780c6db | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24031 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7066678&dopt=citation | en_US |
dc.description.abstract | Opiate alkaloid and opioid peptide actions on spontaneous neuronal activity and postsynaptic amino acid responsiveness were assessed using intracellular recording techniques applied to murine spinal cord neurons in primary dissociated cell culture. Application of opiates was by superfusion and amino acids by iontophoresis. Glycine and GABA but not glutamate responses were antagonized by the opiate alkaloids. Since opiate effects on glycine and GABA responses were not naloxone-reversible, only weakly stereospecific, and not produced by the opioid peptide [-Ala2]-Met-enkephalinamide, it is unlikely that these effects were mediated by opiate receptors. Opiate depression of glycine inhibition was correlated with the induction of paroxysmal depolarizations in cultured spinal cord neurons, suggesting that antagonism of inhibitory amino acid transmission may underlie the convulsant actions of high concentrations of the opiate alkaloids. | en_US |
dc.format.extent | 752158 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neurosciences Program, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A.; (R.L.M.) Department of Neurology, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Neurosciences Program, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A.; (R.L.M.) Department of Neurology, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7066678 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24031/1/0000280.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(82)90038-5 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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