In vitro effects of 10,10'-oxybisphenoxarsine on isolated rat liver mitochondria
dc.contributor.author | Kronenberg, Joel M. | en_US |
dc.contributor.author | Brabec, Michael J. | en_US |
dc.date.accessioned | 2006-04-07T17:55:04Z | |
dc.date.available | 2006-04-07T17:55:04Z | |
dc.date.issued | 1982-02 | en_US |
dc.identifier.citation | Kronenberg, Joel M., Brabec, Michael J. (1982/02)."In vitro effects of 10,10'-oxybisphenoxarsine on isolated rat liver mitochondria." Toxicology and Applied Pharmacology 62(2): 282-287. <http://hdl.handle.net/2027.42/24072> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXH-4DDR041-7G/2/01e5e8a6e910728b28ba930770b97447 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24072 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7058531&dopt=citation | en_US |
dc.description.abstract | 10,10'-Oxybisphenoxarsine (OBPA), a trivalent, heterocyclic organoarsenical, is a potent, broad spectrum antimicrobial agent often incorporated into plasticized polyvinyl chlorides. Although highly toxic, the mechanism of OBPA toxicity is unknown. Since it is hepatotoxic, we investigated the in vitro effects of OBPA on rat liver mitochondria. Isolated mitochondria were incubated with 1 to 8 [mu] OBPA and oxygen consumption was monitored polarographically. State 3 respiration of [alpha]-ketoglutarate, pyruvate, isocitrate, and succinate was rapidly inhibited. OBPA also uncoupled oxidative phosphorylation, although this was masked, at higher concentrations, by progressive respiratory inhibition. The electron transport chain appeared unaffected by OBPA, as measured by NADH oxidation, but several tricarboxcylic acid cycle dehydrogenases were inhibited. This inhibition was prevented and, in some cases, reversed by glutathione. It is likely that OBPA, like other trivalent organoarsenicals, exerts its toxic effects by reacting with vital mitochondrial sulfhydryl groups. | en_US |
dc.format.extent | 412636 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | In vitro effects of 10,10'-oxybisphenoxarsine on isolated rat liver mitochondria | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7058531 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24072/1/0000324.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0041-008X(82)90126-0 | en_US |
dc.identifier.source | Toxicology and Applied Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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