Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: Bicuculline and penicillin
dc.contributor.author | Heyer, Eric J. | en_US |
dc.contributor.author | Nowak, Linda M. | en_US |
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.date.accessioned | 2006-04-07T17:55:12Z | |
dc.date.available | 2006-04-07T17:55:12Z | |
dc.date.issued | 1982-01-28 | en_US |
dc.identifier.citation | Heyer, Eric J., Nowak, Linda M., Macdonald, Robert L. (1982/01/28)."Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: Bicuculline and penicillin." Brain Research 232(1): 41-56. <http://hdl.handle.net/2027.42/24075> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4840K0N-F7/2/0a40a6047ec2291e89a2af270dee5db7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24075 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7055710&dopt=citation | en_US |
dc.description.abstract | The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced membrane depolarization of mouse spinal cord neurons in primary dissociated cell culture by blocking a potassium conductance, a non-synaptic direct effect. Both compounds also prolonged calcium-dependent action potentials of mouse dorsal root ganglion and spinal cord neurons in cell culture. Thus, BICUC and PCN had both synaptic and non-synaptic actions. The possibility that both synaptic and non-synaptic actions of BICUC and PCN are involved in their convulsant mechanism of action is discussed. | en_US |
dc.format.extent | 1003284 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: Bicuculline and penicillin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neurosciences Program, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Neurosciences Program, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A.;Department of Neurology, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Neurosciences Program, University of Michigan Medical Center, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7055710 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24075/1/0000328.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(82)90609-6 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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