Secretion of [alpha]-amylase from parotid lobules of young and old rats
dc.contributor.author | Kim, Sun-Kee | en_US |
dc.contributor.author | Calkins, Debby W. | en_US |
dc.contributor.author | Weinhold, Paul A. | en_US |
dc.date.accessioned | 2006-04-07T17:57:00Z | |
dc.date.available | 2006-04-07T17:57:00Z | |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | Kim, Sun-Kee, Calkins, Debby W., Weinhold, Paul A. (1982)."Secretion of [alpha]-amylase from parotid lobules of young and old rats." Experimental Gerontology 17(5): 387-397. <http://hdl.handle.net/2027.42/24116> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T6J-47RJ36X-1CD/2/26768a2e4fdb1cbe4b6e929d76dce934 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24116 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6188629&dopt=citation | en_US |
dc.description.abstract | The rate of release of a secretory enzyme, [alpha]-amylase, from the parotid lobules of 2 and 24 month old rats has been compared to determine whether the secretory activity of the cells change during aging. Upon incubation in the presence of a secretogogue, isoproterenol (10-5 M), about the same proportions of the glandular [alpha]-amylase are released at about the same rate from these lobules. The isoproterenol-stimulated release of the enzyme is inhibited nearly completely by preincubating the lobules with propranolol (10-5 M) in both age groups, indicating that the enzyme secretion occurs through the stimulation of [beta]-receptors. When viewed in the electron microscope, the cell membranes bordering the secretory lumen in isoproterenol-incubated lobules reveal festooned appearances which suggest that the enzyme release occurs by means of exocytosis. These observations indicate that the ability of the parotid cells to release secretory products through the [beta]-receptor mediation does not significantly change with increasing age. | en_US |
dc.format.extent | 688772 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Secretion of [alpha]-amylase from parotid lobules of young and old rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy The University of Michigan Medical School, USA | en_US |
dc.contributor.affiliationum | Department of Biochemistry, The University of Michigan Medical School, USA | en_US |
dc.contributor.affiliationother | Research Service, V.A. Medical Center, Ann Arbor, Michigan 48105, USA | en_US |
dc.identifier.pmid | 6188629 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24116/1/0000373.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0531-5565(82)90039-0 | en_US |
dc.identifier.source | Experimental Gerontology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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