Dissociation of vascular resistance with endocrine pancreas secretion: The effects of epoxymethano analogs of PGH2
dc.contributor.author | Akpan, Jones O. | en_US |
dc.contributor.author | Hurley, Mary C. | en_US |
dc.contributor.author | Pek, Sumer Belbez | en_US |
dc.contributor.author | Lands, William E. M. | en_US |
dc.date.accessioned | 2006-04-07T17:59:27Z | |
dc.date.available | 2006-04-07T17:59:27Z | |
dc.date.issued | 1981-12 | en_US |
dc.identifier.citation | Akpan, J. O., Hurley, M. C., Pek, S., Lands, W. E. M. (1981/12)."Dissociation of vascular resistance with endocrine pancreas secretion: The effects of epoxymethano analogs of PGH2." Prostaglandines and Medicine 7(6): 473-481. <http://hdl.handle.net/2027.42/24186> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B7GHB-4C3C8BH-C/2/aca57872cd5607a8f89351ca9620c806 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24186 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7034020&dopt=citation | en_US |
dc.description.abstract | The epoxymethano analogs of PGH2 caused rapid and persistent increase in perfusion pressure in isolated rat pancreata without significant effect on glucagon and insulin secretory responses to PGH2 and PGE2. The changes in perfusion pressure are interpreted as alterations in vascular resistance since the flow rate was kept constant at 2.5 mL per min. PGH2 alone caused significant elevation in pressure. However, PGH2 administration superimposed upon an infused epoxymethano analog of PGH2, decreased perfusion pressure significantly, whereas PGH2 induced hormone release was not decreased. The analogs neither stimulated nor inhibited the endocrine pancreas secretion. These studies provide evidence for complete dissociation of vascular constriction from pancreatic hormone release and further suggest that the effects of PGH2 on islet hormone secretion may result from the conversion of PGH2 to other prostanoids. | en_US |
dc.format.extent | 691311 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Dissociation of vascular resistance with endocrine pancreas secretion: The effects of epoxymethano analogs of PGH2 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Endocrinology and Metabolism and The Metabolism Research Unit), The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Endocrinology and Metabolism and The Metabolism Research Unit), The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Endocrinology and Metabolism and The Metabolism Research Unit), The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Endocrinology and Metabolism and The Metabolism Research Unit), The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7034020 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24186/1/0000445.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0161-4630(81)90036-7 | en_US |
dc.identifier.source | Prostaglandines and Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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