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Long-lasting changes in morphine sensitivity following amygdaloid kindling in mice
Mansour, Alfred; Doyle, Richard; Katz, Richard J.; Valenstein, Elliot S.
Mansour, Alfred; Doyle, Richard; Katz, Richard J.; Valenstein, Elliot S.
1981-12
Citation:Mansour, Alfred, Doyle, Richard, Katz, Richard, Valenstein, Elliot S. (1981/12)."Long-lasting changes in morphine sensitivity following amygdaloid kindling in mice." Physiology & Behavior 27(6): 1117-1120. <http://hdl.handle.net/2027.42/24190>
Abstract: Mice tested at either 3, 27 or 90 days following their last amygdala kindled convulsion exhibited a marked increase in response to morphine compared to controls. Kindled animals showed a higher incidence of clonic convulsions and an exaggerated Straub tail response, both of which could be blocked by naloxone pretreatment. The changes in response to morphine produced by kindling may provide a model for studying the long-lasting effects of convulsions.
