The use of kainic acid for studying the origins of scalp-recorded auditory brainstem responses in the guinea pig
dc.contributor.author | Gardi, John N. | en_US |
dc.contributor.author | Bledsoe, Sanford C., Jr. | en_US |
dc.date.accessioned | 2006-04-07T18:00:52Z | |
dc.date.available | 2006-04-07T18:00:52Z | |
dc.date.issued | 1981-10-23 | en_US |
dc.identifier.citation | Gardi, John N., Bledsoe, Jr., Sanford C. (1981/10/23)."The use of kainic acid for studying the origins of scalp-recorded auditory brainstem responses in the guinea pig." Neuroscience Letters 26(2): 143-149. <http://hdl.handle.net/2027.42/24227> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485YFYB-RG/2/70cfa3f8cd6b2f1b597e9e135fc0a820 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24227 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7301202&dopt=citation | en_US |
dc.description.abstract | Kainic acid was injected into the medial nucleus of the trapezoid body (MNTB) of guinea pigs to evaluate its use in studying generator loci of the scalp-recorded auditory brain stem response (ABR). Sound-evoked near-field potentials from the MNTB and far-field ABRs were recorded before, during and up to 2 h after the injections. Two hours post-injection, small amounts of kainic acid (0.25 nmol in 0.1 [mu]l of Ringer solution) resulted in neuronal destruction which histologically appeared confined to the MNTB. Larger amounts (10 nmol in 1.0 [mu]l) produced more extensive lesions. Regardless of the dose of kainic acid, near-field activity evoked by contralateral ear stimulation was almost totally abolished and ABR wave III amplitude was reduced by as much as 60%. In future studies, the use of excitotoxic amino acids to produce lesions within complex nuclear subdivisions of the auditory pathway may yield valuable information as to the relative contributions that brainstem structures make to the various waves comprising the ABR and about the behavioral effects that axon sparing lesions produce. | en_US |
dc.format.extent | 430936 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The use of kainic acid for studying the origins of scalp-recorded auditory brainstem responses in the guinea pig | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Coleman Laboratory, 863-HSE, University of California School of Medicine, San Francisco, CA 94143, U.S.A. | en_US |
dc.identifier.pmid | 7301202 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24227/1/0000487.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(81)90340-2 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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