Is haploid gene expression possible for sperm antigens?
dc.contributor.author | Erickson, Robert P. | en_US |
dc.contributor.author | Lewis, Susan E. | en_US |
dc.contributor.author | Butley, Martin S. | en_US |
dc.date.accessioned | 2006-04-07T18:02:21Z | |
dc.date.available | 2006-04-07T18:02:21Z | |
dc.date.issued | 1981-09 | en_US |
dc.identifier.citation | Erickson, Robert P., Lewis, Susan E., Butley, Martin (1981/09)."Is haploid gene expression possible for sperm antigens?." Journal of Reproductive Immunology 3(4): 195-217. <http://hdl.handle.net/2027.42/24267> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T8W-476NF5J-3B/2/a14812de31aa98b5834c017f84f6bccd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24267 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6168761&dopt=citation | en_US |
dc.description.abstract | The development of a spermatozoon (sperm) from a spermatid involves a complex process of differentiation during which a variety of new gene products appear. It has been generally assumed that no genetic transcription occurs after meiosis and, if this were so, that all the new sperm proteins would have to be transcribed from stored messenger RNA. However, the biochemical evidence suggests that there is no abrupt change in the rate of RNA synthesis during meiosis and that qualitative changes in RNA synthesis, to the extent that they are known, favor the likelihood of continuing messenger RNA synthesis. Experimental analyses of distorted transmission ratios of t-alleles and unbalanced chromosomal states in males also suggest that genes are expressed in haploid nuclei after meiosis. It is probable that spermatozoa are functionally equivalent in most respects because of intercellular bridges that create a continuous cytoplasm between developing spermatozoa, facilitating an exchange of most post-meiotic gene products. Plasma membrane proteins which are potential antigens might not be shared across the intercellular bridges but the evidence to date for haploid expression of sperm antigens is poor. | en_US |
dc.format.extent | 1868842 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Is haploid gene expression possible for sperm antigens? | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6168761 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24267/1/0000532.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0378(81)90042-5 | en_US |
dc.identifier.source | Journal of Reproductive Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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