Dopamine [beta]-hydroxylation in diabetes and diabetic autonomic neuropathy
dc.contributor.author | Hoeldtke, Robert D. | en_US |
dc.contributor.author | Stetson, Philip L. | en_US |
dc.date.accessioned | 2006-04-07T18:03:05Z | |
dc.date.available | 2006-04-07T18:03:05Z | |
dc.date.issued | 1981-08 | en_US |
dc.identifier.citation | Hoeldtke, Robert D., Stetson, Philip L. (1981/08)."Dopamine [beta]-hydroxylation in diabetes and diabetic autonomic neuropathy." Biochemical Medicine 26(1): 67-76. <http://hdl.handle.net/2027.42/24287> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B7G7P-4C4NWKS-7P/2/6a11f07909a8baf4ea75280ba31b33e5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24287 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7295304&dopt=citation | en_US |
dc.description.abstract | Dopamine [beta]-hydroxylase (DBH) has been studied in healthy subjects and diabetic patients, some of whom had autonomic neuropathy. DBH was assayed by a recently described in vivo tritium release method (10,11). Dopamine specifically labeled in the [beta] position, [[beta]-3H]DA, was given intravenously, and the time course of tritiated water (THO) release into the total body water was measure as an index of DBH activity in sympathetic neurons. We simultaneously assayed [3H]norepinephrine metabolite excretion.The DBH activity of patients with autonomic neuropathy as a group did not differ significantly from that of diabetics without neuropathy or healthy controls. Our data do not support the suggestion (7) that a deficit in DBH activity is responsible for sympathetic neuronal dysfunction in diabetic autonomic neuropathy. This syndrome thus differs from idiopathic orthostatic hypotension in which condition there is an impairment in the ability of sympathetic neurons to hydroxylate dopamine (9). | en_US |
dc.format.extent | 565942 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Dopamine [beta]-hydroxylation in diabetes and diabetic autonomic neuropathy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Endocrinology and Metabolism University of Michigan, Ann Arbor, Michigan 48109, USA; the Metabolism Research Unit, University of Michigan, Ann Arbor, Michigan 48109, USA Upjohn Center for Clinical Pharmacology; University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Endocrinology and Metabolism University of Michigan, Ann Arbor, Michigan 48109, USA; the Metabolism Research Unit, University of Michigan, Ann Arbor, Michigan 48109, USA Upjohn Center for Clinical Pharmacology; University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7295304 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24287/1/0000553.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-2944(81)90031-4 | en_US |
dc.identifier.source | Biochemical Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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