Evidence for a regulatory role of CTP : Choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth
dc.contributor.author | Weinhold, Paul A. | en_US |
dc.contributor.author | Feldman, Douglas A. | en_US |
dc.contributor.author | Quade, Mary M. | en_US |
dc.contributor.author | Miller, Joseph C. | en_US |
dc.contributor.author | Brooks, Robert L. | en_US |
dc.date.accessioned | 2006-04-07T18:03:40Z | |
dc.date.available | 2006-04-07T18:03:40Z | |
dc.date.issued | 1981-07-24 | en_US |
dc.identifier.citation | Weinhold, Paul A., Feldman, Douglas A., Quade, Mary M., Miller, Joseph C., Brooks, Robert L. (1981/07/24)."Evidence for a regulatory role of CTP : Choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 665(1): 134-144. <http://hdl.handle.net/2027.42/24304> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1X-47G2PHW-76/2/5f95305f3a89f9ff59f0d922ca5ccd7d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24304 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6269639&dopt=citation | en_US |
dc.description.abstract | The sequence of reactions which function to incorporate choline into phosphatidylcholine was investigated in lung from fetuses following premature delivery. The rate of [methyl-14C]choline incorporation by rat lung slices into phosphatidylcholine increases following premature delivery at both 20 and 21 days gestation. The increase in choline incorporation is primarily due to an increased specific activity of phosphorylcholine resulting from a decreased pool size of phosphorylcholine. The decrease in the concentration of phosphorylcholine following premature delivery is apparently caused by an increased activity of cytidylyltransferase which leads to an increase in the conversion of phosphorylcholine to phosphatidylcholine. The total activity of choline kinase, cytidylyltransferase, cholinephosphotransferase and phosphatidate phosphohydrolase did not change significantly. However, the cytidylyltransferase activity in the microsome fraction increased following premature delivery at 20 and 21 days gestation. The amount of cytidylyltransferase in the H form in the cytosol fraction increased following premature delivery at 21 days gestation but not at 20 days gestation. The results are interpreted to indicate that the active form of cytidylyltransferase in lung cells is the membrane-bound enzyme and this form increases following birth resulting in an increased synthesis of phosphatidylcholine. | en_US |
dc.format.extent | 1188081 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Evidence for a regulatory role of CTP : Choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.identifier.pmid | 6269639 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24304/1/0000570.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2760(81)90241-1 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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