Animal models and human depressive disorders
dc.contributor.author | Katz, Richard J. | en_US |
dc.date.accessioned | 2006-04-07T18:04:33Z | |
dc.date.available | 2006-04-07T18:04:33Z | |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Katz, R. J. (1981)."Animal models and human depressive disorders." Neuroscience & Biobehavioral Reviews 5(2): 231-246. <http://hdl.handle.net/2027.42/24329> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0J-4859SXB-2V/2/02f082ecc4251018d83bd1af60520d59 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24329 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7022272&dopt=citation | en_US |
dc.description.abstract | Clinical depressive disorders are complex in presentation, dissimilar in origins and course, and often pleomorphic in character. An adequate understanding of their origins, biological substrates, and amenability to established and novel forms of therapy demands biological and social interventions which cannot always readily or ethically be carried out in a clinical setting. One useful complementary approach to clinical research utilizes preclinical models for laboratory investigations in parallel. The present paper reviews current approaches to modelling depression using animals, with particular emphasis upon phylogenetic constraints, systematic validity and reliability, and nosological limitations. Preclinical models are useful and necessary adjuncts for adequately understanding depression in humans. However, their utility remains a direct function of a continuing dialogue between clinical and laboratory research, and demands scrupulous observation and methodological rigor on the part of both clinicians and experimental researchers. | en_US |
dc.format.extent | 2082668 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Animal models and human depressive disorders | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 7022272 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24329/1/0000596.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0149-7634(81)90004-X | en_US |
dc.identifier.source | Neuroscience & Biobehavioral Reviews | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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