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Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant
dc.contributor.authorRoth, Kevin A.en_US
dc.contributor.authorKatz, Richard J.en_US
dc.date.accessioned2006-04-07T18:04:37Z
dc.date.available2006-04-07T18:04:37Z
dc.date.issued1981en_US
dc.identifier.citationRoth, K. A., Katz, R. J. (1981)."Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant." Neuroscience &amp; Biobehavioral Reviews 5(2): 253-258. <http://hdl.handle.net/2027.42/24331>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0J-4859SXB-2X/2/422017da0faf410671d1c0ef8a2dd496en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24331
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7196555&dopt=citationen_US
dc.description.abstractWe have previously shown that rats given stress before open field testing have elevated activity in comparison with unstressed rats. This acute behavioral response may be eliminated by chronic stress and restored by pretreatment with the monoamine oxidase inhibitor pargyline. The present study replicated previous findings upon the effects of acute and chronic stress and extended results upon treatment to the class of tricyclic antidepressant drugs, using imipramine as a prototypic tricyclic antidepressant. Imipramine also restored both behavioral and psychoendocrine activity which was otherwise altered by chronic stress.en_US
dc.format.extent488260 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleFurther studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressanten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherNancy Pritzker Laboratory of Behavioral Neurochemistry Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Palo Alto, CA 94305, USAen_US
dc.identifier.pmid7196555en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24331/1/0000598.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0149-7634(81)90006-3en_US
dc.identifier.sourceNeuroscience &amp; Biobehavioral Reviewsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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