Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant
dc.contributor.author | Roth, Kevin A. | en_US |
dc.contributor.author | Katz, Richard J. | en_US |
dc.date.accessioned | 2006-04-07T18:04:37Z | |
dc.date.available | 2006-04-07T18:04:37Z | |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Roth, K. A., Katz, R. J. (1981)."Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant." Neuroscience & Biobehavioral Reviews 5(2): 253-258. <http://hdl.handle.net/2027.42/24331> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0J-4859SXB-2X/2/422017da0faf410671d1c0ef8a2dd496 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24331 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7196555&dopt=citation | en_US |
dc.description.abstract | We have previously shown that rats given stress before open field testing have elevated activity in comparison with unstressed rats. This acute behavioral response may be eliminated by chronic stress and restored by pretreatment with the monoamine oxidase inhibitor pargyline. The present study replicated previous findings upon the effects of acute and chronic stress and extended results upon treatment to the class of tricyclic antidepressant drugs, using imipramine as a prototypic tricyclic antidepressant. Imipramine also restored both behavioral and psychoendocrine activity which was otherwise altered by chronic stress. | en_US |
dc.format.extent | 488260 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Nancy Pritzker Laboratory of Behavioral Neurochemistry Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Palo Alto, CA 94305, USA | en_US |
dc.identifier.pmid | 7196555 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24331/1/0000598.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0149-7634(81)90006-3 | en_US |
dc.identifier.source | Neuroscience & Biobehavioral Reviews | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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