Increased activity of ornithine decarboxylase in goldfish following optic nerve crush
dc.contributor.author | Kohsaka, Shinichi | en_US |
dc.contributor.author | Schwartz, Michal | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2006-04-07T18:05:45Z | |
dc.date.available | 2006-04-07T18:05:45Z | |
dc.date.issued | 1981-06 | en_US |
dc.identifier.citation | Kohsaka, Shinichi, Schwartz, Michal, Agranoff, Bernard W. (1981/06)."Increased activity of ornithine decarboxylase in goldfish following optic nerve crush." Developmental Brain Research 1(3): 391-401. <http://hdl.handle.net/2027.42/24363> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYW-4835PNV-54/2/478665d7c0fe4b6cbac4eacc77878160 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24363 | |
dc.description.abstract | Ornithine decarboxylase (ODC) activity increased in goldfish retina, brain, and kidney several days following unilateral intraorbital optic nerve crush. Activity in both retinas followed a similar time course, an elevation being first detectable 3 days following crush, maximal on day 5 and returning to control levels by day 7. Increases were significantly higher in the retina on the lesioned side than in control retina. If one eye was surgically removed, a more prolonged elevation of ODC activity was seen in the remaining eye than was observed in control retinas following contralateral nerve crush. Sham operation or behavioral stress secondary to aversive electrical shock did not lead to significant increases in ODC activity in brain or retina.Explants of retinas whose optic nerve had been crushed 10-14 days prior to explanation, as well as those derived from the unlesioned side, showed increases in ODC activity following addition of [beta]-NGF to the medium. The response was greater in post-crush retinas than in control retinas.These results taken together suggest an increased responsiveness of the regenerating retina to stimuli that lead to increased ODC activity. While the nature of the in vivo signal(s) may be complex, it is inferred that degenerative changes in the distal stump play a significant role. | en_US |
dc.format.extent | 609177 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Increased activity of ornithine decarboxylase in goldfish following optic nerve crush | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and Mental Health Research Institute, University of Michigan, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and Mental Health Research Institute, University of Michigan, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and Mental Health Research Institute, University of Michigan, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24363/1/0000632.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-3806(81)90076-6 | en_US |
dc.identifier.source | Developmental Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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