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Central epinergic inhibition of corticosterone release in rat
dc.contributor.authorRoth, Kevin A.en_US
dc.contributor.authorKatz, Richard J.en_US
dc.contributor.authorSibel, M.en_US
dc.contributor.authorMefford, I. N.en_US
dc.contributor.authorBarchas, Jack D.en_US
dc.contributor.authorCarroll, Bernard J.en_US
dc.date.accessioned2006-04-07T18:06:08Z
dc.date.available2006-04-07T18:06:08Z
dc.date.issued1981-05-21en_US
dc.identifier.citationRoth, K. A., Katz, R. J., Sibel, M., Mefford, I. N., Barchas, J. D., Carroll, B. J. (1981/05/21)."Central epinergic inhibition of corticosterone release in rat." Life Sciences 28(21): 2389-2394. <http://hdl.handle.net/2027.42/24373>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-477GD6R-6G/2/6cace9e8b721fc3cea5b68098657bb6den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24373
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7253827&dopt=citationen_US
dc.description.abstractDrugs known to inhibit phenylethanolamine-N-methyltransferase (EC 2.1.1.28), the final enzyme in the epinephrine synthetic pathway were administered to rats and their effects on pituitary-arenal function studied. 2, 3-Dichloro-[alpha]-methylbenzylamine (DCMB) produced dose-related increases in plasma corticosterone in basal and stressed rats. Evidence for the central nature of this tonic inhibitory effect of epinephrine was its continued presence in adrenal demedullated rats. 2-chloro-3-trifluoromethyl-[alpha]-benzylamine (CTFMB) administration elevated plasma corticosterone and this effect was highly correlated to the decrease in hypothalamic epinephrine concentration in both sham operated and adrenal demedullated rats. These findings argue for tonic epinergic inhibition of pituitary-adrenal function.en_US
dc.format.extent281221 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCentral epinergic inhibition of corticosterone release in raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute Department of Psychiatry University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute Department of Psychiatry University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute Department of Psychiatry University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherNancy Pritzker Laboratory of Behavioral Neurochemistry Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Stanford, California 94305, USAen_US
dc.contributor.affiliationotherNancy Pritzker Laboratory of Behavioral Neurochemistry Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Stanford, California 94305, USAen_US
dc.contributor.affiliationotherNancy Pritzker Laboratory of Behavioral Neurochemistry Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Stanford, California 94305, USAen_US
dc.identifier.pmid7253827en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24373/1/0000642.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(81)90505-1en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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