Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts
dc.contributor.author | Daddona, Peter E. | en_US |
dc.contributor.author | Kelley, William N. | en_US |
dc.date.accessioned | 2006-04-07T18:07:01Z | |
dc.date.available | 2006-04-07T18:07:01Z | |
dc.date.issued | 1981-04-14 | en_US |
dc.identifier.citation | Daddona, Peter E., Kelley, William N. (1981/04/14)."Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts." Biochimica et Biophysica Acta (BBA) - Enzymology 658(2): 280-290. <http://hdl.handle.net/2027.42/24396> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73GH-47V9CBM-7K/2/542886ae2cd663dfa78e7a8e15804bfd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24396 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6972784&dopt=citation | en_US |
dc.description.abstract | An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is associated with an autosomal recessive form of severe combined immunodeficiency disease. Affected patients exhibit markedly reduced or absent adenosine deaminating activity in various tissues. In this study we have demonstrated the presence of a low level aminohydrolase activity in 11 different normal and adenosine deaminase-deficient lymphoblast cell lines which is apparently distinct from normal adenosine deaminase. Based on enzymatic, physical and immunoreactive properties, this lymphoblast aminohydrolase does not appear to be related to adenosine deaminase and is most likely coded for by a different gene locus. In future investigations designed to characterize mutant forms of adenosine deaminase, it will be important to distinguish this lymphoblast aminohydrolase activity from putative products of the adenosine deaminase gene locus. | en_US |
dc.format.extent | 685839 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biological Chemistry, Human Purine Research Center, The University of Michigan Medical School., Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biological Chemistry, Human Purine Research Center, The University of Michigan Medical School., Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6972784 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24396/1/0000666.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2744(81)90298-9 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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