[alpha]2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment
dc.contributor.author | Smith, Charles B. | en_US |
dc.contributor.author | Garcia-Sevilla, Jesus A. | en_US |
dc.contributor.author | Hollingsworth, Peggie J. | en_US |
dc.date.accessioned | 2006-04-07T18:07:05Z | |
dc.date.available | 2006-04-07T18:07:05Z | |
dc.date.issued | 1981-04-06 | en_US |
dc.identifier.citation | Smith, Charles B., Garcia-Sevilla, Jesus A., Hollingsworth, Peggie J. (1981/04/06)."[alpha]2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment." Brain Research 210(1-2): 413-418. <http://hdl.handle.net/2027.42/24398> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484F4MT-4J/2/bc45624c88ffd53264da89a8cd53963a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24398 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6261876&dopt=citation | en_US |
dc.description.abstract | After two weeks of twice-daily administration of amitriptyline to rats, the binding of [3H]clonidine to presynaptic [alpha]2-adrenoreceptors was decreased in membranes isolated from 5 areas of the rat brain. After one day of treatment, binding did not differ from saline treated controls. In vitro, a high concentration of amitriptyline caused a competitive inhibition of [3H]clonidine binding but did not alter the number of binding sites. The decrease in the number of [alpha]2-adrenoreceptor binding sites after two weeks of amitriptyline treatment would explain the subsensitivity of these receptors which occurs after prolonged administration of antidepressant drugs. | en_US |
dc.format.extent | 398346 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [alpha]2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich. 48109, U.S.A. | en_US |
dc.identifier.pmid | 6261876 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24398/1/0000668.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(81)90919-7 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.