Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine
dc.contributor.author | Schatz, Robert A. | en_US |
dc.contributor.author | Wilens, Timothy E. | en_US |
dc.contributor.author | Sellinger, Otto Z. | en_US |
dc.date.accessioned | 2006-04-07T18:09:15Z | |
dc.date.available | 2006-04-07T18:09:15Z | |
dc.date.issued | 1981-02-27 | en_US |
dc.identifier.citation | Schatz, Robert A., Wilens, Timothy E., Sellinger, Otto Z. (1981/02/27)."Decreased protein and phospholipid methylation after elevation of brain S-adenosyl-homocysteine." Biochemical and Biophysical Research Communications 98(4): 1097-1107. <http://hdl.handle.net/2027.42/24458> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DXRY44-CY/2/2ff087c5eb1270e75490109e0efd4ac0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24458 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7225129&dopt=citation | en_US |
dc.description.abstract | The administration of adenosine together with homocysteine resulted in a dose-related elevation of cerebral S-adenosyl-L-homocysteine without concomitant perturbation of S-adenosyl-L-methionine levels. The adenosine + homocysteine treatment also decreased the incorporation of labile and stable methyl groups into brain proteins. Brain [3H]-phosphatidyl N,N-dimethylethanolamine and [3H]-phosphatidylcholine were also significantly decreased while [3H]-phosphatidyl-N-monomethylethanolamine remained unchanged. The data indicate that elevated brain S-adenosylhomocysteine can markedly and selectively inhibit the methylation of brain proteins and phospholipids. | en_US |
dc.format.extent | 616102 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7225129 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24458/1/0000732.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(81)91224-9 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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