Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan-VI. A search for genotype by environment interaction
dc.contributor.author | Orr, John D. | en_US |
dc.contributor.author | Sing, Charles F. | en_US |
dc.contributor.author | Moll, Patricia Peyser | en_US |
dc.date.accessioned | 2006-04-07T18:13:07Z | |
dc.date.available | 2006-04-07T18:13:07Z | |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Orr, John D., Sing, Charles F., Moll, Patricia P. (1981)."Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan-VI. A search for genotype by environment interaction." Journal of Chronic Diseases 34(11): 545-559. <http://hdl.handle.net/2027.42/24567> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B7GH4-4C0MPBF-1B3/2/1bc8af95ca2d2c0c8e6ef0d4986ef89d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24567 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7287859&dopt=citation | en_US |
dc.description.abstract | We have examined 12 unlinked polymorphic genetic marker systems and found 6 which each identified small but statistically significant differences in normal serum cholesterol levels which did not change significantly with age. The effects associated with 4 of the 6-ABO haptoglobin, Gm and secretor--were consistent in males and females and combined additively to define effects which were also homogeneous over age. There was a marker phenotype by age interaction effect on cholesterol variance in females but not in males. This study supports the hypothesis that a number of polymorphic genes, each with a small additive effect on cholesterol level, play an important role in determining cholesterol variability. | en_US |
dc.format.extent | 1440867 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan-VI. A search for genotype by environment interaction | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.;Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7287859 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24567/1/0000849.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0021-9681(81)90017-5 | en_US |
dc.identifier.source | Journal of Chronic Diseases | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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