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Characterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidine
dc.contributor.authorDjuric, Zoraen_US
dc.contributor.authorSinsheimer, Joseph E.en_US
dc.date.accessioned2006-04-07T18:16:32Z
dc.date.available2006-04-07T18:16:32Z
dc.date.issued1984-12en_US
dc.identifier.citationDjuric, Zora, Sinsheimer, Joseph E. (1984/12)."Characterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidine." Chemico-Biological Interactions 52(2): 243-253. <http://hdl.handle.net/2027.42/24612>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T56-475JFSX-3W/2/14caaa39dc893bc80ee6645bf77b8d01en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24612
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6391705&dopt=citationen_US
dc.description.abstractThymidine was reacted in methanol with four epoxides of varying mutagenicities: propylene oxide, glycidol, epichlorohydrin and trichloropropylene oxide. A single product was detected with each epoxide, and these products had the same retention times on silica high pressure liquid chromatography (HPLC). UV spectra of the products identified them as 3-alkylthymidines, and this was confirmed by infrared (IR) and nuclear magnetic resonance (NMR) spectra. Mass spectra (MS) analysis showed the products to be consistent with attachment at the least substituted carbon of the epoxide. Formation of 3-alkylthymidines correlated to Taft [sigma]* electron withdrawing values for the substituents on the epoxides and mutagenicities in strain TA100 of the Ames Assay.en_US
dc.format.extent790168 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCharacterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid6391705en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24612/1/0000022.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0009-2797(84)90077-2en_US
dc.identifier.sourceChemico-Biological Interactionsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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