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Transduction physiology of olfactory receptor cilia

dc.contributor.authorAdamek, Gloria D.en_US
dc.contributor.authorGesteland, Robert C.en_US
dc.contributor.authorMair, Robert G.en_US
dc.contributor.authorOakley, Bruceen_US
dc.date.accessioned2006-04-07T18:19:34Z
dc.date.available2006-04-07T18:19:34Z
dc.date.issued1984-09-17en_US
dc.identifier.citationAdamek, Gloria D., Gesteland, Robert C., Mair, Robert G., Oakley, Bruce (1984/09/17)."Transduction physiology of olfactory receptor cilia." Brain Research 310(1): 87-97. <http://hdl.handle.net/2027.42/24697>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-4835VV8-6W/2/8db6b6c69ff20b5d9ee6e04dbaff1a1aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24697
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6332659&dopt=citationen_US
dc.description.abstractElectro-olfactograms (EOGs) evoked by 8 odorants from frog olfactory epithelia during ciliary regrowth and during epithelial regeneration were analyzed. During ciliary regrowth following detergent-induced ciliary removal, EOG amplitudes initially increase proportionately with ciliary length. EOGs reach maximal amplitudes after 2 days of growth, when cilia are 40[mu]m long. Therefore olfactory transduction sites are located primarily on cilia rather than on the dendrite terminal and most of the receptor current enters through the proximal portion of the cilium.Zinc sulfate lavage of the nasal cavity causes selective necrosis of the receptor epithelium. During epithelial regeneration, EOGs increase linearly with time from 13 days after zinc lavage, the time of first cilium emergence, through 30 days. The rate of incrase is different for different odorants. At 30 days and within a period of a few days, EOG amplitudes increase abruptly, then asymptote. Thus the development of recetors for different substances occurs at different rates and occurs in two steps. The transition between the two developmental states is coincident with arrival of receptor axon terminals at the central nervous system and with the immobilization of the ciliary contractile apparatus.Since there is continual generation of new receptor neurons throughout life, EOGs recorded in a normal nose reflect a complex combination of the differing receptor processes of cells of diffring developmental stages.en_US
dc.format.extent990416 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleTransduction physiology of olfactory receptor ciliaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationotherGraduate Program in Neuroscience and Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60201, U.S.A.en_US
dc.contributor.affiliationotherGraduate Program in Neuroscience and Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60201, U.S.A.en_US
dc.contributor.affiliationotherGraduate Program in Neuroscience and Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60201, U.S.A.en_US
dc.identifier.pmid6332659en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24697/1/0000116.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(84)90012-Xen_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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