Pathogenesis of hypoxic-ischemic brain injury in a perinatal rodent model
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Buchanan, Karen | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2006-04-07T18:24:30Z | |
dc.date.available | 2006-04-07T18:24:30Z | |
dc.date.issued | 1984-08-31 | en_US |
dc.identifier.citation | SilVerstein, Faye, Buchanan, Karen, Johnston, Michael V. (1984/08/31)."Pathogenesis of hypoxic-ischemic brain injury in a perinatal rodent model." Neuroscience Letters 49(3): 271-277. <http://hdl.handle.net/2027.42/24718> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485YHN1-1H5/2/33213478bb58e67825b2ac2bff459a07 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24718 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6493609&dopt=citation | en_US |
dc.description.abstract | Exposure of immature rats to 8% oxygen after unilateral carotid artery ligation (UCL) causes metabolic, neurochemical and histopathological changes in the ipsilateral forebrain that resemble those in human perinatal hypoxic-ischemic encephalopathy. Regional cerebral perfusion in this model was examined by visual analysis of India ink trapped in cerebral vessels and measurement of [14C]iodoantipyrine ([14C]IAP) and [3H]flunitrazepam extraction into the brain. UCL alone reduced [14C]IAP accumulation in the ipsilateral hemisphere by 20% and hypoxia superimposed on UCL progressively reduced ipsilateral hemisphere perfusion by 71% at 2 h. Hypoxia probably injures neurons in this model by causing a critical reduction in cerebral perfusion, an effect which also appears to be important in the human disorder. | en_US |
dc.format.extent | 352366 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Pathogenesis of hypoxic-ischemic brain injury in a perinatal rodent model | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Center for Human Growth and Development, Ann Arbor, MI 48109, U.S.A.; Department of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Center for Human Growth and Development, Ann Arbor, MI 48109, U.S.A.; Department of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.; Center for Human Growth and Development, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6493609 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24718/1/0000140.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(84)90301-X | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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