Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters
dc.contributor.author | Van Dort, Marcian E. | en_US |
dc.contributor.author | Schwendner, Susan W. | en_US |
dc.contributor.author | Skinner, R. W. Scott | en_US |
dc.contributor.author | Gross, Milton D. | en_US |
dc.contributor.author | Counsell, Raymond E. | en_US |
dc.date.accessioned | 2006-04-07T18:25:58Z | |
dc.date.available | 2006-04-07T18:25:58Z | |
dc.date.issued | 1984-07 | en_US |
dc.identifier.citation | Van Dort, M., Schwendner, S.W., Skinner, R.W.S., Gross, M.D., Counsell, R.E. (1984/07)."Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters." Steroids 44(1): 85-93. <http://hdl.handle.net/2027.42/24760> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TC9-4GJVK4Y-G/2/d001cfa745700a223719e8ed77d406b0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24760 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6537047&dopt=citation | en_US |
dc.description.abstract | A series of radioiodinated pregnenolone esters was prepared in an effort to find an agent that would be rapidly and selectively taken up by adrenal cortical tissue. Achievement of such a goal would provide the basis for the development of an adrenal imaging agent having several advantages over those agents currently available for clinical use. The radioiodinated esters for this study were readily prepared by treating pregnenolone with the appropriate iodobenzoic acid in the presence of dicyclohexylcarbodiimide (DCC) and 4-dimethylamino-pyridine (DMAP). The resulting esters were readily labeled with radioiodine by isotope exchange with sodium iodide-125 in pivalic acid. Subsequent tissue distribution studies in rats revealed that those esters displaying the most stability towards hydrolysis achieved the highest concentration in adrenal cortical tissue. For example, the 2,3,5-triiodobenzoate (6) showed an adrenal uptake of 23% of administered dose per gram of tissue at 0.5 hours. The achievement of high levels of radioactivity in the adrenal with this agent at early time periods warrants further evaluation of this agent in other animals. | en_US |
dc.format.extent | 352582 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Nuclear Medicine Service, Veterans Administration Hospital, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Nuclear Medicine Service, Veterans Administration Hospital, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6537047 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24760/1/0000183.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0039-128X(84)80019-7 | en_US |
dc.identifier.source | Steroids | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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