Synthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl group
dc.contributor.author | Plessas, Nike R. | en_US |
dc.contributor.author | Blake, Diane A. | en_US |
dc.contributor.author | Goldstein, Irwin J. | en_US |
dc.date.accessioned | 2006-04-07T18:26:04Z | |
dc.date.available | 2006-04-07T18:26:04Z | |
dc.date.issued | 1984-07-01 | en_US |
dc.identifier.citation | Plessas, Nike R., Blake, Diane A., Goldstein, Irwin J. (1984/07/01)."Synthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl group." Carbohydrate Research 129(): 143-147. <http://hdl.handle.net/2027.42/24763> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TFF-42NJHCH-2B/2/5856f435a6487e22654a398fd7c6efa4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24763 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6467246&dopt=citation | en_US |
dc.description.abstract | A simple and convenient method for the introduction of radiolabel onto C-6' of N-acetyllactosamine is described. 1-N-Benzyl-3-O-[beta]--galactopyranosyl--arabinosylamine (1) was synthesized from 3-O-[beta]--galactopyranosyl--arabinose as described by Lee and Lee. Compound 1 was oxidized with -galactose oxidase, and the product reduced with KB3H4 to introduce the label at C-6'. After dilution with unlabeled material, the N-benzyl-3-O-[beta]--[6-3H]galactopyranosyl--arabinosylamine was converted into 2-(benzylamino)-2-deoxy-4-O--[6-3H]galactopyranosyl--glucononitrile, which was subjected to simultaneous hydrogenolysis of the benzylamino and nitrile groups. N-Acetylation of the amino group as described by Alais and Veyrieres afforded the crystalline title compound in 63% yield. | en_US |
dc.format.extent | 297589 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl group | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 U.S.A. | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Meharry Medical College, Nashville, Tennesee 37208 U.S.A. | en_US |
dc.identifier.pmid | 6467246 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24763/1/0000186.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0008-6215(84)85306-9 | en_US |
dc.identifier.source | Carbohydrate Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.