View Item 

Show simple item record

Synthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl group
dc.contributor.authorPlessas, Nike R.en_US
dc.contributor.authorBlake, Diane A.en_US
dc.contributor.authorGoldstein, Irwin J.en_US
dc.date.accessioned2006-04-07T18:26:04Z
dc.date.available2006-04-07T18:26:04Z
dc.date.issued1984-07-01en_US
dc.identifier.citationPlessas, Nike R., Blake, Diane A., Goldstein, Irwin J. (1984/07/01)."Synthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl group." Carbohydrate Research 129(): 143-147. <http://hdl.handle.net/2027.42/24763>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TFF-42NJHCH-2B/2/5856f435a6487e22654a398fd7c6efa4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24763
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6467246&dopt=citationen_US
dc.description.abstractA simple and convenient method for the introduction of radiolabel onto C-6' of N-acetyllactosamine is described. 1-N-Benzyl-3-O-[beta]--galactopyranosyl--arabinosylamine (1) was synthesized from 3-O-[beta]--galactopyranosyl--arabinose as described by Lee and Lee. Compound 1 was oxidized with -galactose oxidase, and the product reduced with KB3H4 to introduce the label at C-6'. After dilution with unlabeled material, the N-benzyl-3-O-[beta]--[6-3H]galactopyranosyl--arabinosylamine was converted into 2-(benzylamino)-2-deoxy-4-O--[6-3H]galactopyranosyl--glucononitrile, which was subjected to simultaneous hydrogenolysis of the benzylamino and nitrile groups. N-Acetylation of the amino group as described by Alais and Veyrieres afforded the crystalline title compound in 63% yield.en_US
dc.format.extent297589 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthesis of N-acetyllactosamine containing a -[6-3H]galactopyranosyl groupen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 U.S.A.en_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 U.S.A.en_US
dc.contributor.affiliationotherDepartment of Biochemistry, Meharry Medical College, Nashville, Tennesee 37208 U.S.A.en_US
dc.identifier.pmid6467246en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24763/1/0000186.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0008-6215(84)85306-9en_US
dc.identifier.sourceCarbohydrate Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000186.pdf
Size:
290.6KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.