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Sensitive gas-liquid chromatographic-electron-capture detection method for determination of sobrerol in biological fluids
dc.contributor.authorShukla, Umesh A.en_US
dc.contributor.authorStetson, Philip L.en_US
dc.contributor.authorWagner, John G.en_US
dc.date.accessioned2006-04-07T18:26:45Z
dc.date.available2006-04-07T18:26:45Z
dc.date.issued1984-06-08en_US
dc.identifier.citationShukla, Umesh A., Stetson, Philip L., Wagner, John G. (1984/06/08)."Sensitive gas-liquid chromatographic-electron-capture detection method for determination of sobrerol in biological fluids." Journal of Chromatography: Biomedical Applications 308(): 189-197. <http://hdl.handle.net/2027.42/24781>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG9-47J6T0G-P/2/a0fd4e50bd861b42b2558c9ae074a8bben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24781
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6746813&dopt=citationen_US
dc.description.abstractA sensitive gas--liquid chromatographic assay for sobrerol in biological fluids has been developed. The assay procedure involves esterification of both hydroxyl groups of sobrerol with pentafluoropropionic anhydride to form the diester which can be quantitated using gas--liquid chromatography--electron-capture detection. The detection limit of plasma sobrerol under the conditions described is 5 ng/ml. The assay procedure permits the measurement of unchanged drug in plasma, whole blood or urine in the presence of its metabolites.en_US
dc.format.extent437843 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSensitive gas-liquid chromatographic-electron-capture detection method for determination of sobrerol in biological fluidsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUpjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationotherCollege of Pharmacy, and Upjohn Center for Clinical Pharmacology, The Unviersity of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid6746813en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24781/1/0000205.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4347(84)80208-Xen_US
dc.identifier.sourceJournal of Chromatography: Biomedical Applicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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