Resolution in the receptor binding of putative [mu] and [kappa] opiates
dc.contributor.author | Medzihradsky, Fedor | en_US |
dc.contributor.author | Dahlstrom, Patricia J. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Fischel, Steven V. | en_US |
dc.contributor.author | Mitsos, Stephanie E. | en_US |
dc.date.accessioned | 2006-04-07T18:27:51Z | |
dc.date.available | 2006-04-07T18:27:51Z | |
dc.date.issued | 1984-05-28 | en_US |
dc.identifier.citation | Medzihradsky, Fedor, Dahlstrom, Patricia J., Woods, James H., Fischel, Steven V., Mitsos, Stephanie E. (1984/05/28)."Resolution in the receptor binding of putative [mu] and [kappa] opiates." Life Sciences 34(22): 2129-2138. <http://hdl.handle.net/2027.42/24812> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-474Y8P4-8P/2/6265b7d8ebb19a64ffd30b924706820d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24812 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6145076&dopt=citation | en_US |
dc.description.abstract | Conditions for the stereospecific binding of 3H-ethylketocyclazocine and 3H-etorphine were established in membranes from rat and pigeon brain. In displacing the specific binding of the radiolabeled ligands, putative [mu] and [kappa] opiates displayed different sensitivity toward sodium. In membranes from both species, the ratio of the sodium responses exhibited by a given drug in displacing 3H-ethylketocyclazocine and 3H-etorphine, respectively, ("double sodium ratio" = DSR) distinguished between [mu] and [kappa] opiates. Compounds characterized on the basis of their pharmacological effects as [kappa] opiates had DSR values between 0.3 and 2.2, regardless of their nature as agonists or antagonists. In contrast, the DSR for [mu] opiates ranged from 3.4 to 11. In rat brain membranes, UM 1382 (U-50, 488, a compound with pronounced [kappa] activity) exhibited a DSR of 0.3, while the corresponding value for morphine was 7.4. Dynorphin-(1-13) had a DSR of 1. Within each of the two groups, the simple sodium ratio continued to serve as an index for the agonist or antagonist property of the tested opiates. | en_US |
dc.format.extent | 547857 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Resolution in the receptor binding of putative [mu] and [kappa] opiates | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 6145076 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24812/1/0000238.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(84)90311-4 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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