Genetic effects on quantitative variation in serologically detected H-Y antigen
dc.contributor.author | Shapiro, Mark | en_US |
dc.contributor.author | Erickson, Robert P. | en_US |
dc.date.accessioned | 2006-04-07T18:28:23Z | |
dc.date.available | 2006-04-07T18:28:23Z | |
dc.date.issued | 1984-05 | en_US |
dc.identifier.citation | Shapiro, Mark, Erickson, Robert P. (1984/05)."Genetic effects on quantitative variation in serologically detected H-Y antigen." Journal of Reproductive Immunology 6(3): 197-210. <http://hdl.handle.net/2027.42/24828> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T8W-476NF12-1K/2/16e708d73e89a71183ce45554465752c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24828 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6376798&dopt=citation | en_US |
dc.description.abstract | We have examined effects of an autosomal gene on the expression of serologically detectable H-Y, a male-specific minor histocompatibility antigen for which a role in primary sex determination has been postulated. Quantitative immunoabsorption studies using three different male specific antisera revealed variation in the level of H-Y among inbred mouse strains and mice bearing variants of the T/t complex. Two patterns of expression in inbred strains were observed; high, C57BL/6J (B6) and low, which included A/J (A), C3H/DiSn and DBA/2J. In F1 hybrids between A (female parent) and B6 (male parent), the F1 expressed H-Y levels indistinguishable from A, the low parent. Among T/t complex variants, mice bearing T or t0 showed high expression whereas those of the t12 haplotype showed low expression. The co-segregation of H-Y expression types with these T/t complex variants provided further evidence for the location of a gene determining the level of H-Y antigen on the proximal portion of chromosome 17. | en_US |
dc.format.extent | 793420 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Genetic effects on quantitative variation in serologically detected H-Y antigen | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, USA | en_US |
dc.identifier.pmid | 6376798 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24828/1/0000254.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0378(84)90025-1 | en_US |
dc.identifier.source | Journal of Reproductive Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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