Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat
dc.contributor.author | Beyer, Robert E. | en_US |
dc.contributor.author | Starnes, Joseph W. | en_US |
dc.contributor.author | Edington, Dee W. | en_US |
dc.contributor.author | Lipton, Richard J. | en_US |
dc.contributor.author | Compton, III, Ralph T. | en_US |
dc.contributor.author | Kwasman, Michael A. | en_US |
dc.date.accessioned | 2006-04-07T18:30:35Z | |
dc.date.available | 2006-04-07T18:30:35Z | |
dc.date.issued | 1984-03 | en_US |
dc.identifier.citation | Beyer, Robert E., Starnes, Joseph W., Edington, Dee W., Lipton, Richard J., Compton, III, Ralph T., Kwasman, Michael A. (1984/03)."Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat." Mechanisms of Ageing and Development 24(3): 309-323. <http://hdl.handle.net/2027.42/24891> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T31-47PG2MF-CH/2/c70111b2c4c351bf5f4f94506b5c21e3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24891 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6717094&dopt=citation | en_US |
dc.description.abstract | The ability of gastrocnemius muscle homogenates to catalyze the oxidation of succinate, glutamate + malate, pyruvate + malate, palmitoyl-coenzyme A, decanoylcarnitine and palmitoylcarnitine in the presence of ADP decreased by approximately 32% in sedentary male Sprague-Dawley rats between the ages of 9 and 25 months. Following 21 weeks of treadmill training (running), such homogenates from 25-month-old animals catalyzed oxidations 55% more rapidly than those from 25-month-old sedentary rats, and 17% faster than those from 9-month-old sedentary rats. Total and peptide-bound flavin of gastrocnemius muscles also declined between 9 and 25 months of age and were elevated in the 25-month-old endurance trained rats to levels greater than both 9- and 25-month-old sedentary animals. The yield of protein in the mitochondrial fraction from the quadriceps femoris muscle decreased between 9 and 25 months and was restored to the 9-month level by endurance training. The kinetic characteristics of the isolated mitochondria were not influenced by age or exercise. These data indicate that 2-year-old rats retain the capacity to increase skeletal muscle oxidative capacity and mitochondrial population density in response to endurance training. | en_US |
dc.format.extent | 829178 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6717094 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24891/1/0000318.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0047-6374(84)90116-7 | en_US |
dc.identifier.source | Mechanisms of Ageing and Development | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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