Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity : Mediation by glucocorticoid receptors
dc.contributor.author | Barouski-Miller, Patricia A. | en_US |
dc.contributor.author | Gelehrter, Thomas D. | en_US |
dc.date.accessioned | 2006-04-07T18:31:59Z | |
dc.date.available | 2006-04-07T18:31:59Z | |
dc.date.issued | 1984-02 | en_US |
dc.identifier.citation | Barouski-Miller, Patricia A., Gelehrter, Thomas D. (1984/02)."Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity : Mediation by glucocorticoid receptors." Journal of Steroid Biochemistry 20(2): 533-537. <http://hdl.handle.net/2027.42/24927> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73GT-47F296W-P/2/8ed385ce2f3c593a6e7e444973702ff4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24927 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6142981&dopt=citation | en_US |
dc.description.abstract | Dexamethasone, a synthetic glucocorticoid, decreases the plasminogen activator (PA) activity of HTC rat hepatoma cells in tissue culture. Paradoxically, dexamethasone enhances the cyclic nucleotide stimulation of PA activity in these cells 2-4-fold. In this report, we investigated whether this paradoxical glucocorticoid effect is mediated by the same proximal events which mediate such direct regulatory actions of glucocorticoids as the induction of tyrosine aminotransferase activity. We compared the concentration-dependences for several classes of steroids, previously classified as full agonists, partial agonists, antagonists or inactive steroids with respect to induction of the transaminase, for both enhancement of cyclic nucleotide stimulation of PA activity and induction of tyrosine aminotransferase activity in parallel cultures. The full agonists dexamethasone and cortisol, the partial agonists deoxycorticosterone and 11[beta]-hydroxyprogesterone, the inactive steroid tetrahydrocortisol, and the antagonist 17[alpha]-methyltestosterone exhibited similar potencies with respect to both phenomena. Furthermore, when cells were incubated with both dexamethasone and 17[alpha]-methyltestosterone, the latter blocked enhancement by dexamethasone in a concentration-dependent fashion. We conclude that glucocorticoid enhancement of cyclic nucleotide stimulation of PA activity is mediated by the same glucocorticoid receptors which mediate direct regulatory effects. | en_US |
dc.format.extent | 628250 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity : Mediation by glucocorticoid receptors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6142981 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24927/1/0000354.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4731(84)90120-1 | en_US |
dc.identifier.source | Journal of Steroid Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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