Comparison of plasma cortisol and corticosterone in the dexamethasone suppression test for melancholia
dc.contributor.author | Wilens, Timothy E. | en_US |
dc.contributor.author | Ritchie, James C. | en_US |
dc.contributor.author | Carroll, Bernard J. | en_US |
dc.date.accessioned | 2006-04-07T18:32:46Z | |
dc.date.available | 2006-04-07T18:32:46Z | |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | Wilens, Timothy E., Ritchie, James C., Carroll, Bernard J. (1984)."Comparison of plasma cortisol and corticosterone in the dexamethasone suppression test for melancholia." Psychoneuroendocrinology 9(1): 45-55. <http://hdl.handle.net/2027.42/24951> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TBX-484NBHH-6P/2/b8fe558b3a73fe2468a3f7158e9824cd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24951 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6739664&dopt=citation | en_US |
dc.description.abstract | The suppression of plasma corticosterone (B), measured by radioimmunoassay (RIA), was compared to simultaneous suppression of plasma cortisol (F), measured as total corticoids by a competitive protein binding (CPB) assay, in the overnight dexamethasone suppression test (DST). Baseline plasma B concentrations in IO control subjects were 4.04 +/- 1.07 ng/ml (X +/- S.D.) at 0800 hr and 1.51 +/- 0.68 ng/ml at 1600 hr. Post-dexamethasone 1600 hr B levels in the controls were 0.46 +/- 0.29 ng/ml. An early escape of plasma B (> 1.2 ng/ml), like that of F (> 5 [mu]g/dl), during the overnight 24 hr 1.0 mg dose DST was noted in patients with melancholia (endogenous depression).Half-hourly catheter samples in a normal subject stimulated to escape from dexamethasone suppression showed that in general, plasma B concentrations parallel plasma F concentrations over a 12 hr period. Repeated weekly DSTs on two patients with different psychiatric diagnoses resulted in B: F correlations of 0.74 and 0.60. Overall agreement between B- and F-DST outcomes in all categories tested at 1600 and 2300 hr was 93%; the agreement in the melancholic and non-endogenous depressed groups was 100%.Post-dexamethasone, both B and F were suppressed 55-60% below the criterion level in controls. In those patients who escaped from dexamethasone suppression, the percentage increase in plasma B above the criterion level was significantly greater (+ 55%) than the corresponding percentage change in plasma F. Most patients with borderline abnormal F-DSTs (3.5-4.9 [mu]g/dl) exhibited clearly abnormal B-DSTs (> 1.2 ng/ml). We conclude that the use of dexamethasone suppression of plasma B (using 1.2 ng/ml as the abnormal criterion value) is an additional indicator of an abnormal DST in depressed patients. | en_US |
dc.format.extent | 733600 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Comparison of plasma cortisol and corticosterone in the dexamethasone suppression test for melancholia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Studies Unit and Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit and Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit and Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6739664 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24951/1/0000378.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0306-4530(84)90021-0 | en_US |
dc.identifier.source | Psychoneuroendocrinology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.