High incidence of neoplasms in female NZB/NZW mice treated with pulse doses of cyclophosphamide
dc.contributor.author | Walker, Sara Ellen | en_US |
dc.contributor.author | Anver, Miriam R. | en_US |
dc.date.accessioned | 2006-04-07T18:37:05Z | |
dc.date.available | 2006-04-07T18:37:05Z | |
dc.date.issued | 1983-11 | en_US |
dc.identifier.citation | Walker, S. E., Anver, M. R. (1983/11)."High incidence of neoplasms in female NZB/NZW mice treated with pulse doses of cyclophosphamide." Veterinary Immunology and Immunopathology 5(1): 97-104. <http://hdl.handle.net/2027.42/25065> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TD5-476VGM1-C/2/24540b5d2637de9bc0c493d591099dca | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25065 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6606891&dopt=citation | en_US |
dc.description.abstract | The immunosuppressive properties of cyclophosphamide prevent formation of anti-DNA antibodies and prolong lifespans in autoimmune NZB/NZW mice, an animal model of systemic lupus erythematosus. In the current study, NZB/NZW mice were treated with weekly doses of cyclophosphamide to determine if intermittent pulses of the drug were effective therapy. Life-long treatment with cyclophosphamide, 56 mg/kg/week, was started at the mean age of 6 weeks; results were compared with saline-injected control mice. Pulse therapy with cyclophosphamide suppressed anti-DNA antibody levels, prevented severe qlomerulonephritis and prolonged longevity. Seventeen of 19 treated mice developed neoplasms; 7 of these immunosuppressed animals had 2 to 4 separate neoplasms. Examination of earlier studies in this laboratory in which NZB/NZW mice were treated each day with cyclophosphamide showed that daily and weekly therapeutic regimens had similar immunosuppressive and oncogenic effects. | en_US |
dc.format.extent | 361137 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | High incidence of neoplasms in female NZB/NZW mice treated with pulse doses of cyclophosphamide | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6606891 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25065/1/0000496.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-2427(83)90035-1 | en_US |
dc.identifier.source | Veterinary Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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