Free fatty acids in an animal model of reye's syndrome

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dc.contributor.author Deshmukh, Devendra R. en_US
dc.contributor.author Deshmukh, Gayatri D. en_US
dc.contributor.author Shope, Thomas C. en_US
dc.contributor.author Radin, Norman S. en_US
dc.date.accessioned 2006-04-07T18:38:39Z
dc.date.available 2006-04-07T18:38:39Z
dc.date.issued 1983-09-20 en_US
dc.identifier.citation Deshmukh, Devendra R., Deshmukh, Gayatri D., Shope, Thomas C., Radin, Norman S. (1983/09/20)."Free fatty acids in an animal model of reye's syndrome." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 753(2): 153-158. <http://hdl.handle.net/2027.42/25111> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T1X-47F7FGM-N1/2/8c82099bf87fb93743766fb662acd655 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/25111
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6615853&dopt=citation en_US
dc.description.abstract Recent studies have indicated that viral infections, aspirin treatment and hyperammonemia are associated with Reye's syndrome. It has also been reported that free fatty acids in serum and total lipids in the liver of Reye's syndrome patients are elevated during illness. The role of the lipid changes in the development of the disorder cannot be optimally studied in human patients, because infection and aspirin ingestion occur prior to the earliest symptoms of Reye's syndrome. Effects of influenza B infection, aspirin treatment and hyperammonemia on the level of free fatty acids, total lipids and triacylglycerols in serum and liver of an animal model of Reye's syndrome are reported here. Hyperammonemia was produced in young, male ferrets either by feeding them small amounts of an arginine-deficient diet after overnight fasting or by an intraperitoneal injection of jackbean urease. The ferret model resembled Reye's syndrome in developing increased levels of individual and total serum free fatty acids, liver triacylglycerol and total lipids. The results also indicate that influenza infection or aspirin treatment, or both, while increasing the severity of encephalopathy in the deficient ferrets, did not cause a significant change in the level of serum free fatty acids. Other results suggest that elevation of serum ammonia, serum free fatty acid or liver lipids, either singly or in various combinations, does not provide conditions that can explain the rapidly developing encephalopathy in the arginine-deficient ferrets. en_US
dc.format.extent 564927 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Free fatty acids in an animal model of reye's syndrome en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Materials Science and Engineering en_US
dc.subject.hlbsecondlevel Chemistry en_US
dc.subject.hlbsecondlevel Chemical Engineering en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Engineering en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Pediatrics and Communicable, Diseases, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Pediatrics and Communicable, Diseases, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.identifier.pmid 6615853 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/25111/1/0000543.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0005-2760(83)90002-4 en_US
dc.identifier.source Biochimica et Biophysica Acta en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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