Low molecular weight dextran in experimental pancreatitis: Effects on pancreatic microcirculation
dc.contributor.author | Knol, James A. | en_US |
dc.contributor.author | Edgcomb, Leslie P. | en_US |
dc.contributor.author | Inman, Mark G. | en_US |
dc.contributor.author | Eckhauser, Frederic E. | en_US |
dc.date.accessioned | 2006-04-07T18:40:39Z | |
dc.date.available | 2006-04-07T18:40:39Z | |
dc.date.issued | 1983-07 | en_US |
dc.identifier.citation | Knol, James A., Edgcomb, Leslie P., Inman, Mark G., Eckhauser, Frederic E. (1983/07)."Low molecular weight dextran in experimental pancreatitis: Effects on pancreatic microcirculation." Journal of Surgical Research 35(1): 73-82. <http://hdl.handle.net/2027.42/25168> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNG27B-DC/2/7b2f2dbb4de4a8a7bdfc9826fa4a1cbb | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25168 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6191124&dopt=citation | en_US |
dc.description.abstract | Although low molecular weight (LMW) dextran has been said to decrease the lethality of experimental acute pancreatitis (AP) by reversing stasis in the pancreatic microcirculation, the actual mechanism(s) of action is unknown. This investigation was designed to measure the effects of low molecular weight dextran on pancreatic capillary flow (QCAP) and arteriovenous shunt flow (QAVS), and on pancreatic oxygen consumption (O2CP) following bile-trypsin-induced AP in dogs. Total pancreatic blood flow (QT) was measured with an electromagnetic flow probe on the superior pancreaticoduodenal artery (SPDA). QAVS was measured by liver trapping of 99mTc-albumin microspheres after SPDA injection. QCAP was calculated as QT minus QAVS. Seventeen dogs were treated with lactated Ringer's (LR) solution at 6.5 ml/kg/hr; 10 dogs were treated with LMW dextran 10% in normal saline at 1.5 ml/kg/hr plus LR at 5.0 ml/kg/hr. Mean arterial and central venous pressures remained constant throughout the 4-hr experiment. In the dogs receiving LR only, QT decreased from 42.7 to 24.4 ml/min (P QAVS remained constant at 1.35 +/- 0.04 ml/min. During the first 30 min O2CP decreased from 1.17 to 0.76 ml O2/min (P QT and QCAP without altering QAVS. The decrease in O2CP in association with a constant QAVS suggests a metabolic block to oxygen uptake at the cellular level. Continuous infusion of LMW dextran at a dose of 1.5 ml/kg/hr in the dog does not reverse these abnormalities. | en_US |
dc.format.extent | 855370 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Low molecular weight dextran in experimental pancreatitis: Effects on pancreatic microcirculation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA; Surgical Research Laboratories, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA; Surgical Research Laboratories, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA; Surgical Research Laboratories, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA; Surgical Research Laboratories, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA | en_US |
dc.identifier.pmid | 6191124 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25168/1/0000606.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(83)90128-2 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.