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Kinetics of tissue distribution and elimination of 4,4'-methylene bis(2-chloroaniline) in rats
dc.contributor.authorTobes, Michael C.en_US
dc.contributor.authorBrown, Lawrence E.en_US
dc.contributor.authorChin, Bruceen_US
dc.contributor.authorMarsh, David D.en_US
dc.date.accessioned2006-04-07T18:41:43Z
dc.date.available2006-04-07T18:41:43Z
dc.date.issued1983-06en_US
dc.identifier.citationTobes, Michael C., Brown, Lawrence E., Chin, Bruce, Marsh, David D. (1983/06)."Kinetics of tissue distribution and elimination of 4,4'-methylene bis(2-chloroaniline) in rats." Toxicology Letters 17(1-2): 69-75. <http://hdl.handle.net/2027.42/25193>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCR-477XSPH-B9/2/295b62d319c74160be33df5ba2991548en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25193
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6623511&dopt=citationen_US
dc.description.abstractThe tissue distribution kinetics and elimination of 4,4'-methylene bis(2-chloroaniline) (MBOCA) in rats was studied after a single dose of [14C]MBOCA (0.49 mg/kg body weight, i.V.). The highest concentrations of radioactivity were in the small intestine, liver, adipose, lung, kidney, skin, and adrenals. For most tissues, a rapid decrease in radioactivity was followed by a slower decrease except for the small intestine, adipose and skin which demonstrated transient increases. Subcellular distribution in liver at 1 h showed radioactivity in all cell fractions. Although very lipophilic, [14C]MBOCA was completely eliminated within 48 h with the major route via the feces (73.4%).en_US
dc.format.extent413216 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleKinetics of tissue distribution and elimination of 4,4'-methylene bis(2-chloroaniline) in ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNuclear Medicine Division, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumNuclear Medicine Division, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Environment and Industrial Health, The University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumNuclear Medicine Division, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid6623511en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25193/1/0000632.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4274(83)90037-1en_US
dc.identifier.sourceToxicology Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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