Phosphodiesteratic breakdown of endogenous polyphosphoinositides in nerve ending membranes
dc.contributor.author | Van Rooijen, Lucio A. A. | en_US |
dc.contributor.author | Seguin, Edward B. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2006-04-07T18:42:33Z | |
dc.date.available | 2006-04-07T18:42:33Z | |
dc.date.issued | 1983-05-16 | en_US |
dc.identifier.citation | Van Rooijen, Lucio A. A., Seguin, Edward B., Agranoff, Bernard W. (1983/05/16)."Phosphodiesteratic breakdown of endogenous polyphosphoinositides in nerve ending membranes." Biochemical and Biophysical Research Communications 112(3): 919-926. <http://hdl.handle.net/2027.42/25217> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DP5MPT-47/2/b69a97a1a7aa52988ad8a259224ec1ed | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25217 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6303341&dopt=citation | en_US |
dc.description.abstract | When a membrane preparation, obtained by freezing and thawing nerve endings labeled by preincubation with 32Pi, is incubated in the presence of millimolar Ca2+, there is a rapid and selective loss of label from the polyphosphoinositides and a concomitant increase in labeled inositol di- and triphosphates recovered. When the membranes are not prelabeled and are exposed to [[gamma]-32P]ATP under similar conditions, phosphatidate labeling is enhanced, indicating increased availability of diacylglycerol. These observations provide evidence for the presence of membrane-bound, Ca2+-stimulated phosphodiesterase activity (phospholipase C) acting on endogenous polyphosphoinositides. The implications of these findings are discussed in respect to the "phosphatidylinositol" cycle. | en_US |
dc.format.extent | 962207 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Phosphodiesteratic breakdown of endogenous polyphosphoinositides in nerve ending membranes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA; Neuroscience Laboratory, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA; Neuroscience Laboratory, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA; Neuroscience Laboratory, University of Michigan, 1103 East Huron, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 6303341 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25217/1/0000657.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(83)91705-9 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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