II. Biochemical mechanisms in the phosphatidylinositol effect
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2006-04-07T18:42:41Z | |
dc.date.available | 2006-04-07T18:42:41Z | |
dc.date.issued | 1983-05-02 | en_US |
dc.identifier.citation | Agranoff, Bernard W. (1983/05/02)."II. Biochemical mechanisms in the phosphatidylinositol effect." Life Sciences 32(18): 2047-2054. <http://hdl.handle.net/2027.42/25221> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4789VXD-3S/2/843bf2d6e9e237b0ebe495cc0d9cdd89 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25221 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6843282&dopt=citation | en_US |
dc.description.abstract | Stimulated labeling of phospholipids from 32Pi is a hallmark of activation of a variety of cell surface receptors. In the case of the central nervous system, the response can reflect muscarinic activation. Recent studies in nerve ending preparations indicate a postsynaptic site of action. Ca2+ is required for the expression of cholinergic stimulation of labeling in nerve ending preparations, but whether it plays a regulatory role is not yet known. While it is inferred that the receptor-ligand interaction leads to increased diacylglycerol availability, its source is not established. In experiments with muscarinic agents and ionophore added to nerve ending preparations, there is a potentiated loss of labeling from prelabeled polyphosphoinositides. It is suggested that phosphodiesteratic cleavage of polyphosphoinositides may be an early consequence of muscarinic receptor activation. | en_US |
dc.format.extent | 417450 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | II. Biochemical mechanisms in the phosphatidylinositol effect | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory University of Michigan 1103 East Huron, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6843282 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25221/1/0000661.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(83)90092-9 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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