Clinicopathologic features of Chandler's syndrome
dc.contributor.author | Patel, Arun | en_US |
dc.contributor.author | Kenyon, Kenneth R. | en_US |
dc.contributor.author | Hirst, Lawrence W. | en_US |
dc.contributor.author | Quigley, Harry A. | en_US |
dc.contributor.author | Stark, Walter J. | en_US |
dc.contributor.author | Meyer, Roger F. | en_US |
dc.contributor.author | Green, W. Richard | en_US |
dc.date.accessioned | 2006-04-07T18:45:02Z | |
dc.date.available | 2006-04-07T18:45:02Z | |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | Patel, Arun, Kenyon, Kenneth R., Hirst, Lawrence W., Quigley, Harry A., Stark, Walter J., Meyer, Roger F., Green, W. Richard (1983)."Clinicopathologic features of Chandler's syndrome." Survey of Ophthalmology 27(5): 327-344. <http://hdl.handle.net/2027.42/25286> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCC-4C35NVK-7/2/9a4bd758221cd6b67382409781dfaef5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25286 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6344293&dopt=citation | en_US |
dc.description.abstract | The clinicopathologic features of Chandler's syndrome are elucidated based on a study of nine patients. Keratoplasty, trabeculectomy and/or iris specimens were studied by light, electron and, in six cases, specular microscopy. The prominent pathologic features were abnormalities of the endothelially-derived cells lining the posterior corneal surface, the inner surface of the trabecular meshwork, and the anterior iris surface. In all four corneal buttons, the endothelium was diffusely attenuated and focally absent, and posterior collagen layers were present. Extension of the endothelial cell layer and Descemet's membrane deposition over the trabecular meshwork were observed in two trabeculectomy specimens, and similar proliferation onto the anterior surface of the iris was evident in four iris specimens. Other abnormalities of the endothelial cells included increased intracytoplasmic filaments. These pathologic alterations are consistent with the concept of Chandler's syndrome as representing one variant of the iridocorneal endothelial (ICE) syndrome. Interestingly, although both endothelial proliferative and degenerative responses can be observed in Chandler's syndrome, their occurrence within the same eye is apparently not simultaneous. | en_US |
dc.format.extent | 3624941 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Clinicopathologic features of Chandler's syndrome | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA | en_US |
dc.contributor.affiliationother | The Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; The Cornea Service of the Massachusetts Eye and Ear Infirmary, the Department of Cornea Research and Morphology Unit, Eye Research Institute of the Retinal Foundation, Boston, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA | en_US |
dc.contributor.affiliationother | Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA | en_US |
dc.contributor.affiliationother | Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA | en_US |
dc.contributor.affiliationother | Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA; Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA | en_US |
dc.identifier.pmid | 6344293 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25286/1/0000729.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0039-6257(83)90234-5 | en_US |
dc.identifier.source | Survey of Ophthalmology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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