Identification of N5-methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine as a major adduct in rat liver DNA after treatment with the carcinogens, N,N-dimethylnitrosamine or 1,2-dimethylhydrazine
dc.contributor.author | Beranek, D. T. | en_US |
dc.contributor.author | Weis, C. C. | en_US |
dc.contributor.author | Evans, F. E. | en_US |
dc.contributor.author | Chetsanga, Christopher J. | en_US |
dc.contributor.author | Kadlubar, Fred F. | en_US |
dc.date.accessioned | 2006-04-07T18:46:14Z | |
dc.date.available | 2006-04-07T18:46:14Z | |
dc.date.issued | 1983-01-27 | en_US |
dc.identifier.citation | Beranek, D. T., Weis, C. C., Evans, F. E., Chetsanga, C. J., Kadlubar, F. F. (1983/01/27)."Identification of N5-methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine as a major adduct in rat liver DNA after treatment with the carcinogens, N,N-dimethylnitrosamine or 1,2-dimethylhydrazine." Biochemical and Biophysical Research Communications 110(2): 625-631. <http://hdl.handle.net/2027.42/25317> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DN9B4W-273/2/4c0fa7e5203f006e1c575ce10679e44c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25317 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6838542&dopt=citation | en_US |
dc.description.abstract | A major and previously undetected carcinogen-DNA adduct was found in the livers of rats given N,N-dimethylnitrosamine or 1,2-dimethylhydrazine. This adduct, which accounted for 55% of the total methyl residues in DNA at 72 hours after carcinogen treatment, was chromatographically identical to a synthetic purine ring-opened derivative of 7-methylguanine and could be released from the isolated hepatic DNA by a specific glycosylase. The synthetic ring-opened adduct was characterized by mass and NMR spectroscopy as N5-methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine and appears to exist in two rotameric forms. | en_US |
dc.format.extent | 440399 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Identification of N5-methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine as a major adduct in rat liver DNA after treatment with the carcinogens, N,N-dimethylnitrosamine or 1,2-dimethylhydrazine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan-Dearborn, Dearborn, MI 48128, USA | en_US |
dc.contributor.affiliationother | National Center for Toxicological Research (HFT-110), Food and Drug Administration, Jefferson, AR 72079, USA | en_US |
dc.contributor.affiliationother | National Center for Toxicological Research (HFT-110), Food and Drug Administration, Jefferson, AR 72079, USA | en_US |
dc.contributor.affiliationother | National Center for Toxicological Research (HFT-110), Food and Drug Administration, Jefferson, AR 72079, USA | en_US |
dc.contributor.affiliationother | National Center for Toxicological Research (HFT-110), Food and Drug Administration, Jefferson, AR 72079, USA | en_US |
dc.identifier.pmid | 6838542 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25317/1/0000762.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(83)91195-6 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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