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Partial characterization of neurotoxic esterase of human placenta
dc.contributor.authorGurba, Paul E.en_US
dc.contributor.authorRichardson, Rudy J.en_US
dc.date.accessioned2006-04-07T18:47:06Z
dc.date.available2006-04-07T18:47:06Z
dc.date.issued1983-01en_US
dc.identifier.citationGurba, Paul. E., Richardson, Rudy J. (1983/01)."Partial characterization of neurotoxic esterase of human placenta." Toxicology Letters 15(1): 13-17. <http://hdl.handle.net/2027.42/25337>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCR-477Y3HP-264/2/07914eaafa32f62412e15b38d29ccec0en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25337
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6836585&dopt=citationen_US
dc.description.abstractNeurotoxic esterase (NTE), the putative target for organophosphorus-induced delayed axonopathy, has been found in preparations of human placenta. The activity was primarily found in membrane-enriched fractions rather than high-speed supernatant. NTE was solubilized from a mixture of mitochondrial and microsomal membranes with Triton X-100. The crude and solubilized activities had inhibitor characteristics similar to preparations from avian brain. Because of the similarities to NTE from brain and ready availability, human placenta may be an ideal source for the bulk purification of a human form of the enzyme.en_US
dc.format.extent348145 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePartial characterization of neurotoxic esterase of human placentaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumToxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumToxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid6836585en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25337/1/0000783.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4274(83)90162-5en_US
dc.identifier.sourceToxicology Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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