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Glucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2
dc.contributor.authorLeach, Karen L.en_US
dc.contributor.authorDahmer, Mary K.en_US
dc.contributor.authorPratt, William B.en_US
dc.date.accessioned2006-04-07T18:48:10Z
dc.date.available2006-04-07T18:48:10Z
dc.date.issued1983-01en_US
dc.identifier.citationLeach, Karen L., Dahmer, Mary K., Pratt, William B. (1983/01)."Glucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2." Journal of Steroid Biochemistry 18(1): 105-107. <http://hdl.handle.net/2027.42/25367>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B73GT-47F27VF-R9/2/07960b439450a07c93927c0fb5e02771en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25367
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6865402&dopt=citationen_US
dc.description.abstractGlucocorticoid receptors in cytosol preparations from rat liver or mouse L cells are inactivated by phospholipase A2 or calf intestine alkaline phosphatase. Molybdate ion, an inhibitor of a variety of phosphatase enzymes, does not prevent inactivation of glucocorticoid binding capacity by alkaline phosphatase but it blocks inactivation by phospholipase A2. In neither case is the enzyme itself inhibited, and the effect of molybdate on phospholipase-mediated inactivation appears to reflect the ability of molybdate to prevent receptor inactivation by the detergent action of lysophosphatides.en_US
dc.format.extent387673 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGlucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid6865402en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25367/1/0000816.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-4731(83)90337-0en_US
dc.identifier.sourceJournal of Steroid Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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