Systemic and intracerebroventricular effects of opioid peptides in withdrawn morphine-dependent rhesus monkeys
dc.contributor.author | Gmerek, Debra E. | en_US |
dc.contributor.author | Katz, Jonathan L. | en_US |
dc.contributor.author | France, Charles P. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.date.accessioned | 2006-04-07T18:49:44Z | |
dc.date.available | 2006-04-07T18:49:44Z | |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | Gmerek, Debra E., Katz, Jonathan L., France, Charles P., Woods, James H. (1983)."Systemic and intracerebroventricular effects of opioid peptides in withdrawn morphine-dependent rhesus monkeys." Life Sciences 33(Supplement 1): 361-364. <http://hdl.handle.net/2027.42/25411> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4754CDX-1K1/2/0d4e28b02284f650e9f0602ea07caa84 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25411 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6686632&dopt=citation | en_US |
dc.description.abstract | The effects of the degradation-resistant enkephalin analogs FK 33-824 and metkephamid were determined after systemic and intracerebroventricular (i.c.v.) administration in withdrawn morphine-dependent rhesus monkeys. Both peptides suppressed completely signs of 12-hr morphine deprivation, as does the prototype mu-receptor agonist morphine. The peptides were 100 and 2000 times more potent, respectively, after i.c.v. than s.c. injection. Thus, although peptidase-resistant, these compounds have restricted entrance into the central nervous system after systemic administration. The i.c.v. administration of compounds in rhesus monkeys should prove to be a valuable tool in the study of peptide ligands for opiate receptors. | en_US |
dc.format.extent | 219275 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Systemic and intracerebroventricular effects of opioid peptides in withdrawn morphine-dependent rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6686632 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25411/1/0000860.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(83)90517-9 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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