Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death
dc.contributor.author | Holland, Kurt J. | en_US |
dc.contributor.author | Patterson, Eugene | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T18:50:41Z | |
dc.date.available | 2006-04-07T18:50:41Z | |
dc.date.issued | 1983-05 | en_US |
dc.identifier.citation | Holland, Kurt, Patterson, Eugene, Lucchesi, Benedict R. (1983/05)."Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death." American Heart Journal 105(5): 711-717. <http://hdl.handle.net/2027.42/25438> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4CN4HPP-81/2/a32ebbccc72b576d6d91d90ea1b1d502 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25438 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6846113&dopt=citation | en_US |
dc.description.abstract | In anesthetized dogs, a silver wire electrode was inserted into the lumen of the circumflex coronary artery (LCX) and myocardial infarction was produced by a temporary 90-minute occlusion of the left anterior descending coronary artery (LAD) followed by reperfusion. Four days later while in the ambulatory state, a 150 [mu]A current was applied to the intimal surface of the LCX of saline (n = 10) and bretylium (n = 10) treated animal. Intimal injury and coronary thrombosis produced ST segment changes at 138 +/- 39 minutes ([chi] +/- SEM), followed by premature ventricular beats (at 142 +/- 37 minutes), ventricular tachycardia (at 156 +/- 49 minutes), and ventricular fibrillation (at 163 +/- 51 minutes) in 9 of 10 saline-treated animals. In bretylium-treated animals, ST segment changes appeared at 128 +/- 35 minutes, with six animals surviving for 24 hours (p < 0.03 vs saline). LAD infarction was present in both saline (14.1 +/- 2.3%) and bretylium (15.1 +/- 2.1% of left ventricle) treated animals with only bretylium-treated animals developing LCX infarcts (16.1 +/- 2.1%). Bretylium prevents ventricular fibrillation (VF) resulting from ischemia at a site distant to prior myocardial infarction in the conscious dog and deserves further attention as a potential antifibrillatory agent for prevention of sudden coronary death in man. | en_US |
dc.format.extent | 2172266 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA. | en_US |
dc.identifier.pmid | 6846113 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25438/1/0000888.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(83)90229-6 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.