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Development and characterization of cold-adapted viruses for use as live virus vaccines

dc.contributor.authorMaassab, Hunein F.en_US
dc.contributor.authorDeBorde, Dan C.en_US
dc.date.accessioned2006-04-07T18:53:33Z
dc.date.available2006-04-07T18:53:33Z
dc.date.issued1985-12en_US
dc.identifier.citationMaassab, H. F., DeBorde, Dan C. (1985/12)."Development and characterization of cold-adapted viruses for use as live virus vaccines." Vaccine 3(5): 355-369. <http://hdl.handle.net/2027.42/25479>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TD4-476TV06-7K/2/47762eb5201c967a2503e7e132d29c41en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25479
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3909681&dopt=citationen_US
dc.description.abstractRepresentative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.en_US
dc.format.extent1631524 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDevelopment and characterization of cold-adapted viruses for use as live virus vaccinesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid3909681en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25479/1/0000019.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0264-410X(85)90124-0en_US
dc.identifier.sourceVaccineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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