Development and characterization of cold-adapted viruses for use as live virus vaccines
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | DeBorde, Dan C. | en_US |
dc.date.accessioned | 2006-04-07T18:53:33Z | |
dc.date.available | 2006-04-07T18:53:33Z | |
dc.date.issued | 1985-12 | en_US |
dc.identifier.citation | Maassab, H. F., DeBorde, Dan C. (1985/12)."Development and characterization of cold-adapted viruses for use as live virus vaccines." Vaccine 3(5): 355-369. <http://hdl.handle.net/2027.42/25479> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TD4-476TV06-7K/2/47762eb5201c967a2503e7e132d29c41 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25479 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3909681&dopt=citation | en_US |
dc.description.abstract | Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus. | en_US |
dc.format.extent | 1631524 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Development and characterization of cold-adapted viruses for use as live virus vaccines | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3909681 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25479/1/0000019.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0264-410X(85)90124-0 | en_US |
dc.identifier.source | Vaccine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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