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Enzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomes
dc.contributor.authorMarker, Elizabeth K.en_US
dc.contributor.authorKulkarni, Arun P.en_US
dc.date.accessioned2006-04-07T19:01:45Z
dc.date.available2006-04-07T19:01:45Z
dc.date.issued1985-08en_US
dc.identifier.citationMarker, Elizabeth K., Kulkarni, Arun P. (1985/08)."Enzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomes." Toxicology Letters 26(2-3): 181-185. <http://hdl.handle.net/2027.42/25607>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCR-477XWVR-122/2/c015ed8160adf99e366beeb7c19123f5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25607
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4035711&dopt=citationen_US
dc.description.abstractHepatic microsomes from 5 strains of untreated mice were tested for the ability to enzymatically cleave the nitro group from 2-nitropropane (2NP). All strains showed significant NADPH-dependent nitrite release at pH 7.6 and pH 8.8. Statistical differences in nitrite-releasing activity between strains were found between BALB and PL/J and ATH strains at pH 7.6. At pH 8.8, BIO.M differed from CD-1 and BALB. These results are in contrast to a report of little or no denitrification activity in uninduced rats and suggest that the 2NP microsomal metabolism may be of greater importance than previously thought.en_US
dc.format.extent405195 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleEnzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumToxicology Program, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumToxicology Program, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid4035711en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25607/1/0000154.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4274(85)90164-Xen_US
dc.identifier.sourceToxicology Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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