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Loss of calmodulin activity in cardiac sarcoplasmic reticulum after ischemia
dc.contributor.authorTurla, Mila B.en_US
dc.contributor.authorGnegy, Margaret E.en_US
dc.contributor.authorEpps, Susanen_US
dc.contributor.authorShlafer, Marshalen_US
dc.date.accessioned2006-04-07T19:02:19Z
dc.date.available2006-04-07T19:02:19Z
dc.date.issued1985-07-31en_US
dc.identifier.citationTurla, Mila B., Gnegy, Margaret E., Epps, Susan, Shlafer, Marshal (1985/07/31)."Loss of calmodulin activity in cardiac sarcoplasmic reticulum after ischemia." Biochemical and Biophysical Research Communications 130(2): 617-620. <http://hdl.handle.net/2027.42/25616>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DYVHVW-1J6/2/5de33bfe1a1e8fb67099f8add2fa8dd3en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25616
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4026851&dopt=citationen_US
dc.description.abstractExperiments were designed to evaluate whether cardiac ischemia affected the subcellular distribution of calmodulin activity. Major cellular fractions (nuclei, mitochondria, sarcoplasmic reticulum and cytosol) were isolated from globally ischemic hearts by differential centrifugation. Ischemia did not affect calmodulin activity in cell fractions other than sarcoplasmic reticulum, which showed a consistent and complete loss of activity. This site-specific loss of calmodulin activity may be one mechanism by which ischemia induces contractile dysfunction.en_US
dc.format.extent275583 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLoss of calmodulin activity in cardiac sarcoplasmic reticulum after ischemiaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0010, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0010, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0010, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0010, USAen_US
dc.identifier.pmid4026851en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25616/1/0000164.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(85)90461-9en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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