IV. Effects of bombesin on behavior
dc.contributor.author | Cowan, Alan | en_US |
dc.contributor.author | Khunawat, P. | en_US |
dc.contributor.author | Zhu, X. Zu | en_US |
dc.contributor.author | Gmerek, Debra E. | en_US |
dc.date.accessioned | 2006-04-07T19:02:28Z | |
dc.date.available | 2006-04-07T19:02:28Z | |
dc.date.issued | 1985-07-15 | en_US |
dc.identifier.citation | Cowan, A., Khunawat, P., Zhu, X. Zu, Gmerek, D. E. (1985/07/15)."IV. Effects of bombesin on behavior." Life Sciences 37(2): 135-145. <http://hdl.handle.net/2027.42/25618> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4754B92-12N/2/e95cf28eac1f192beec3c926243ee17e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25618 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2409426&dopt=citation | en_US |
dc.description.abstract | This report describes the influence of bombesin on the gross behavior of goldfish, frogs, mice, rats, guinea pigs, rabbits, chicks, pigeons and monkeys. Goldfish, frogs, chicks and pigeons were overtly unaffected by bombesin given centrally and/or peripherally. Mice, rats, guinea pigs, rabbits and monkeys responded quickly to intracerebroventricular (i.c.v.) and/or intrathecal (i.th.) administration of bombesin by displaying a range of behaviors suggestive of altered skin sensation. In mice, bombesin was essentially equipotent as a scratch inducer by i.c.v. and i.th. routes (A50 = 0.010-0.019 [mu]g) but 6800 times less potent i.p. In rats, bombesin-induced grooming and scratching behaviors were shown to be qualitatively different from those associated with ACTH- (1-24) and thyrotropin releasing hormone. Spantide and [D-Arg1, D-Pro2, D-Trp7,9, Leu11] substance P (both at 0.20, 0.50 and 0.80 [mu]g i.c.v.), two proposed bombesin receptor antagonists, did not markedly influence bombesin-induced scratching or hypothermia in rats. | en_US |
dc.format.extent | 874731 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | IV. Effects of bombesin on behavior | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. | en_US |
dc.identifier.pmid | 2409426 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25618/1/0000166.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(85)90416-3 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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