[beta]-Endorphin suppression of acute morphine abstinence in morphine dependent monkeys: Effective given intraventricularly but ineffective given intravenously
dc.contributor.author | Domino, Edward F. | en_US |
dc.contributor.author | Li, Choh Hao | en_US |
dc.date.accessioned | 2006-04-07T19:03:33Z | |
dc.date.available | 2006-04-07T19:03:33Z | |
dc.date.issued | 1985-07 | en_US |
dc.identifier.citation | Domino, Edward F., Li, Choh Hao (1985/07)."[beta]-Endorphin suppression of acute morphine abstinence in morphine dependent monkeys: Effective given intraventricularly but ineffective given intravenously." Neuropeptides 6(4): 343-350. <http://hdl.handle.net/2027.42/25633> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WNR-4C48BVG-1F/2/bcc87b32f9e8bf3d2ba96889ed8370e8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25633 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2931615&dopt=citation | en_US |
dc.description.abstract | Six female adult monkeys were made dependent upon morphine sulfate and were implanted with a chronic indwelling needle in the lateral ventricle of the brain for sterile intraventricular injections. Both [beta]-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute morphine abstinence. On a molar basis, [beta]-endorphin was more active than morphine in suppressing the signs of morphine abstinence. When given intravenously in much larger doses, [beta]-endorphin was ineffective in contrast to morphine which was effective in suppressing abstinence. | en_US |
dc.format.extent | 462980 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [beta]-Endorphin suppression of acute morphine abstinence in morphine dependent monkeys: Effective given intraventricularly but ineffective given intravenously | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Laboratory of Molecular Endocrinology, University of California, San Francisco, CA 94143, USA | en_US |
dc.identifier.pmid | 2931615 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25633/1/0000183.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0143-4179(85)90007-1 | en_US |
dc.identifier.source | Neuropeptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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