Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes
dc.contributor.author | Nair, Madhavan P. N. | en_US |
dc.contributor.author | Schwartz, Stanley A. | en_US |
dc.contributor.author | Slade, Herbert B. | en_US |
dc.contributor.author | Johnson, Mary Z. | en_US |
dc.contributor.author | Quebbeman, James F. | en_US |
dc.contributor.author | Beer, Alan E. | en_US |
dc.date.accessioned | 2006-04-07T19:05:11Z | |
dc.date.available | 2006-04-07T19:05:11Z | |
dc.date.issued | 1985-05 | en_US |
dc.identifier.citation | Nair, Madhavan P. N., Schwartz, Stanley A., Slade, Herbert B., Johnson, Mary Z., Quebbeman, James F., Beer, Alan E. (1985/05)."Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes." Journal of Reproductive Immunology 7(3): 199-213. <http://hdl.handle.net/2027.42/25675> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T8W-476VS35-3T/2/bf542d758a1bc430eedf82893c4e71ad | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25675 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2410614&dopt=citation | en_US |
dc.description.abstract | Colostral lymphocytes (CL) from mothers 2 to 4 days post-partum and autologous maternal peripheral blood lymphocytes (PBL) were investigated for (1) natural killer (NK) and antibody-dependent cellular cytotoxic (ADCC) activities, (2) target binding ability, (3) interferon (IFN)- and interleukin 2 (IL2)-induced augmentation of NK activity, (4) lectin-dependent cellular cytotoxicity (LDCC), and (5) the ability of culture-derived soluble suppressor factor(s) to inhibit the NK activity of normal allogeneic lymphocytes. CL depleted of adherent cells and Percoll-separated NK-enriched subpopulations of CL demonstrated significantly lower NK and ADCC activities compared to autologous PBL. However, the target binding ability of CL was comparable to autologous PBL. Although the residual NK activity of CL was augmented by IFN and IL2, the activity was not enhanced to the same level shown by autologous PBL. CL also demonstrated a significant enhancement of LDCC activity, although the activity was not stimulated to the levels shown by PBL. Culture supernates of CL manifested greater suppression of the NK ability of allogeneic PBL than culture supernates produced by autologous PBL. These results are consistent with a model that suggests differential partitioning of lymphocyte subpopulations between colostrum and peripheral blood. | en_US |
dc.format.extent | 896817 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 2410614 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25675/1/0000228.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0378(85)90051-8 | en_US |
dc.identifier.source | Journal of Reproductive Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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