Arachidonic acid metabolites regulate interleukin-1 production
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.date.accessioned | 2006-04-07T19:06:19Z | |
dc.date.available | 2006-04-07T19:06:19Z | |
dc.date.issued | 1985-04-30 | en_US |
dc.identifier.citation | Kunkel, S. L., Chensue, S. W. (1985/04/30)."Arachidonic acid metabolites regulate interleukin-1 production." Biochemical and Biophysical Research Communications 128(2): 892-897. <http://hdl.handle.net/2027.42/25698> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DYN48C-156/2/f2f03aaadf71db7152b098245a3f6e64 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25698 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3922370&dopt=citation | en_US |
dc.description.abstract | We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal macrophages. Indomethacin a potent inhibitor of prostaglandin synthesis caused a dose-dependent augmentation of lipopolysaccharide induced interleukin production (up to 7-fold at 5 [mu]M). In contrast, lipoxygenase inhibitors, nordihydroguarietic acid and nafazatrom had no effect at doses that did not significantly decrease prostaglandin synthesis. Added to lipopolysaccharide stimulated cultures, PGE2 suppressed interleukin in a dose-dependent manner. Zymosan induced interleukin was also augmented by indomethacin but unlike lipopolysaccharide treated cultures was suppressed by nordihydroguarietic acid. These data suggest that arachidonate metabolites may be potent autoregulators of macrophage interleukin-1 production. | en_US |
dc.format.extent | 361573 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Arachidonic acid metabolites regulate interleukin-1 production | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3922370 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25698/1/0000252.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(85)90130-5 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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